Older adults' adherence to medications and willingness to deprescribe: A substudy of a randomized clinical trial.

Autor: Weir KR; Sydney School of Public Health, Faculty of Medicine and Health, University of Sydney, Sydney, Australia.; Institute of Primary Health Care BIHAM, University of Bern, Bern, Switzerland., Jungo KT; Sydney School of Public Health, Faculty of Medicine and Health, University of Sydney, Sydney, Australia.; Institute of Primary Health Care BIHAM, University of Bern, Bern, Switzerland.; Center for Healthcare Delivery Sciences, Brigham and Women's Hospital, Boston, Massachusetts, USA.; Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA., Streit S; Sydney School of Public Health, Faculty of Medicine and Health, University of Sydney, Sydney, Australia.; Institute of Primary Health Care BIHAM, University of Bern, Bern, Switzerland.
Jazyk: angličtina
Zdroj: British journal of clinical pharmacology [Br J Clin Pharmacol] 2024 Mar; Vol. 90 (3), pp. 905-911. Date of Electronic Publication: 2023 Dec 07.
DOI: 10.1111/bcp.15966
Abstrakt: Our study investigated the association between patients' willingness to have medications deprescribed and medication adherence. This longitudinal substudy of the 'Optimizing PharmacoTherapy In the Multimorbid Elderly in Primary CAre' (OPTICA) trial, a cluster randomized controlled trial, took place in Swiss primary care settings. Participants were aged ≥65 years and over, with ≥3 chronic conditions and ≥5 regular medications. At baseline, the 'revised Patient Attitudes Towards Deprescribing' (rPATD) questionnaire was measured. The A14-scale measured adherence (self-report) at the 12-month follow-up. Multilevel linear regression analyses adjusted for baseline variables were performed. Of the 298 participants, 45% were women, and the median age was 78. Participants reported a high level of adherence and willingness to have medications deprescribed. We did not find evidence for an association between patients' willingness to deprescribe and medication adherence. Further research is needed to explore the relationship between these concepts and to inform collaborative decisions about medicines in the context of polypharmacy.
(© 2023 The Authors. British Journal of Clinical Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society.)
Databáze: MEDLINE
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