DrugBank 6.0: the DrugBank Knowledgebase for 2024.

Autor:	Knox C; OMx Personal Health Analytics, Inc., 700-10130 103 St NW, Edmonton, AB T5J 1B9, Canada., Wilson M; OMx Personal Health Analytics, Inc., 700-10130 103 St NW, Edmonton, AB T5J 1B9, Canada., Klinger CM; OMx Personal Health Analytics, Inc., 700-10130 103 St NW, Edmonton, AB T5J 1B9, Canada., Franklin M; OMx Personal Health Analytics, Inc., 700-10130 103 St NW, Edmonton, AB T5J 1B9, Canada., Oler E; Department of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada., Wilson A; OMx Personal Health Analytics, Inc., 700-10130 103 St NW, Edmonton, AB T5J 1B9, Canada., Pon A; OMx Personal Health Analytics, Inc., 700-10130 103 St NW, Edmonton, AB T5J 1B9, Canada., Cox J; OMx Personal Health Analytics, Inc., 700-10130 103 St NW, Edmonton, AB T5J 1B9, Canada., Chin NEL; OMx Personal Health Analytics, Inc., 700-10130 103 St NW, Edmonton, AB T5J 1B9, Canada., Strawbridge SA; OMx Personal Health Analytics, Inc., 700-10130 103 St NW, Edmonton, AB T5J 1B9, Canada., Garcia-Patino M; OMx Personal Health Analytics, Inc., 700-10130 103 St NW, Edmonton, AB T5J 1B9, Canada., Kruger R; Department of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada., Sivakumaran A; Department of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada., Sanford S; Department of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada., Doshi R; Department of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada., Khetarpal N; Department of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada., Fatokun O; Department of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada., Doucet D; Department of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada., Zubkowski A; Department of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada., Rayat DY; Department of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada., Jackson H; Department of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada., Harford K; Department of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada., Anjum A; Department of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada., Zakir M; Department of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada., Wang F; Department of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada., Tian S; Department of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada., Lee B; Department of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada., Liigand J; Department of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada.; Institute of Chemistry, University of Tartu, Tartu, Estonia., Peters H; Department of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada., Wang RQR; OMx Personal Health Analytics, Inc., 700-10130 103 St NW, Edmonton, AB T5J 1B9, Canada., Nguyen T; OMx Personal Health Analytics, Inc., 700-10130 103 St NW, Edmonton, AB T5J 1B9, Canada., So D; OMx Personal Health Analytics, Inc., 700-10130 103 St NW, Edmonton, AB T5J 1B9, Canada., Sharp M; OMx Personal Health Analytics, Inc., 700-10130 103 St NW, Edmonton, AB T5J 1B9, Canada., da Silva R; OMx Personal Health Analytics, Inc., 700-10130 103 St NW, Edmonton, AB T5J 1B9, Canada., Gabriel C; OMx Personal Health Analytics, Inc., 700-10130 103 St NW, Edmonton, AB T5J 1B9, Canada., Scantlebury J; OMx Personal Health Analytics, Inc., 700-10130 103 St NW, Edmonton, AB T5J 1B9, Canada., Jasinski M; OMx Personal Health Analytics, Inc., 700-10130 103 St NW, Edmonton, AB T5J 1B9, Canada., Ackerman D; OMx Personal Health Analytics, Inc., 700-10130 103 St NW, Edmonton, AB T5J 1B9, Canada., Jewison T; OMx Personal Health Analytics, Inc., 700-10130 103 St NW, Edmonton, AB T5J 1B9, Canada., Sajed T; Department of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada., Gautam V; Department of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada., Wishart DS; Department of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada.; Department of Computing Science, University of Alberta, Edmonton, AB T6G 2E8, Canada.; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB T6G 2H1, Canada.; Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB T6G 1C9, Canada.
Jazyk:	angličtina
Zdroj:	Nucleic acids research [Nucleic Acids Res] 2024 Jan 05; Vol. 52 (D1), pp. D1265-D1275.
DOI:	10.1093/nar/gkad976
Abstrakt:	First released in 2006, DrugBank (https://go.drugbank.com) has grown to become the 'gold standard' knowledge resource for drug, drug-target and related pharmaceutical information. DrugBank is widely used across many diverse biomedical research and clinical applications, and averages more than 30 million views/year. Since its last update in 2018, we have been actively enhancing the quantity and quality of the drug data in this knowledgebase. In this latest release (DrugBank 6.0), the number of FDA approved drugs has grown from 2646 to 4563 (a 72% increase), the number of investigational drugs has grown from 3394 to 6231 (a 38% increase), the number of drug-drug interactions increased from 365 984 to 1 413 413 (a 300% increase), and the number of drug-food interactions expanded from 1195 to 2475 (a 200% increase). In addition to this notable expansion in database size, we have added thousands of new, colorful, richly annotated pathways depicting drug mechanisms and drug metabolism. Likewise, existing datasets have been significantly improved and expanded, by adding more information on drug indications, drug-drug interactions, drug-food interactions and many other relevant data types for 11 891 drugs. We have also added experimental and predicted MS/MS spectra, 1D/2D-NMR spectra, CCS (collision cross section), RT (retention time) and RI (retention index) data for 9464 of DrugBank's 11 710 small molecule drugs. These and other improvements should make DrugBank 6.0 even more useful to a much wider research audience ranging from medicinal chemists to metabolomics specialists to pharmacologists. (© The Author(s) 2023. Published by Oxford University Press on behalf of Nucleic Acids Research.)
Databáze:	MEDLINE
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