Transcriptomic signature of bacteria exposed to benzalkonium chloride.

Autor: McCarlie SJ; Department of Microbiology and Biochemistry, University of the Free State, South Africa., du Preez LL; Research & HPC: ICT Services, University of the Free State, South Africa., Hernandez JC; Department of Microbiology and Biochemistry, University of the Free State, South Africa., Boucher CE; Department of Microbiology and Biochemistry, University of the Free State, South Africa., Bragg RR; Department of Microbiology and Biochemistry, University of the Free State, South Africa. Electronic address: braggrr@ufs.ac.za.
Jazyk: angličtina
Zdroj: Research in microbiology [Res Microbiol] 2024 May-Jun; Vol. 175 (4), pp. 104151. Date of Electronic Publication: 2023 Nov 10.
DOI: 10.1016/j.resmic.2023.104151
Abstrakt: The COVID-19 pandemic has highlighted our reliance on biocides, the increasing prevalence of resistance to biocides is a risk to public health. Bacterial exposure to the biocide, benzalkonium chloride (BAC), resulted in a unique transcriptomic profile, characterised by both a short and long-term response. Differential gene expression was observed in four main areas: motility, membrane composition, proteostasis, and the stress response. A metabolism shift to protect the proteome and the stress response were prioritised suggesting these are main resistance mechanisms. Whereas "well-established" mechanisms, such as biofilm formation, were not found to be differentially expressed after exposure to BAC.
Competing Interests: Declaration of competing interest The authors have no conflict of interest to disclose.
(Copyright © 2023 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.)
Databáze: MEDLINE
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