The CXCL10-CXCR3 axis plays an important role in Kawasaki disease.

Autor:	Hosaka S; Department of Pediatrics, University of Tsukuba Hospital, Tsukuba City, Japan., Imagawa K; Department of Pediatrics, University of Tsukuba Hospital, Tsukuba City, Japan.; Department of Child Health, Faculty of Medicine, University of Tsukuba, Tsukuba City, Japan., Yano Y; Department of Pediatrics, University of Tsukuba Hospital, Tsukuba City, Japan.; Department of Pediatric Cardiology, Ibaraki Children's Hospital, Mito City, Japan., Lin L; Department of Child Health, Faculty of Medicine, University of Tsukuba, Tsukuba City, Japan.; Department of Pediatric Cardiology, Ibaraki Children's Hospital, Mito City, Japan., Shiono J; Department of Pediatric Cardiology, Ibaraki Children's Hospital, Mito City, Japan., Takahashi-Igari M; Department of Pediatrics, Tsukuba Medical Center Hospital, Tsukuba City, Japan., Hara H; Department of Pediatrics, Tsukuba Medical Center Hospital, Tsukuba City, Japan., Hayashi D; Department of Pediatrics, Tsukuba Medical Center Hospital, Tsukuba City, Japan., Imai H; Department of Pediatrics, Tsukuba Medical Center Hospital, Tsukuba City, Japan., Morita A; Department of Pediatrics, University of Tsukuba Hospital, Tsukuba City, Japan., Fukushima H; Department of Pediatrics, University of Tsukuba Hospital, Tsukuba City, Japan.; Department of Child Health, Faculty of Medicine, University of Tsukuba, Tsukuba City, Japan., Takada H; Department of Pediatrics, University of Tsukuba Hospital, Tsukuba City, Japan.; Department of Child Health, Faculty of Medicine, University of Tsukuba, Tsukuba City, Japan.
Jazyk:	angličtina
Zdroj:	Clinical and experimental immunology [Clin Exp Immunol] 2024 Mar 12; Vol. 216 (1), pp. 104-111.
DOI:	10.1093/cei/uxad125
Abstrakt:	The precise pathogenesis of Kawasaki disease remains unknown. In an attempt to elucidate the pathogenesis of KD through the analysis of acquired immunity, we comprehensively examined the immunophenotypic changes in immune cells such as lymphocytes and monocytes along with various cytokines, focusing on differences between pre- and post- treatment samples. We found high levels of CXCL9 and CXCL10 chemokines that decreased with treatment, which coincided with a post-treatment expansion of Th1 cells expressing CXCR3. Our results show that the CXCL10-CXCR3 axis plays an important role in the pathogenesis of KD. (© The Author(s) 2023. Published by Oxford University Press on behalf of the British Society for Immunology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu