Cardiorespiratory fitness (V̇O 2peak ) across the adult lifespan in persons with multiple sclerosis and matched healthy controls.

Autor: Schlagheck ML; Division of Performance and Health, Institute for Sport and Sport Science, Technical University Dortmund, Germany. Electronic address: marit.schlagheck@tu-dortmund.de., Bansi J; Department of Research and Development, Kliniken Valens, Switzerland; OST - Eastern Swiss University of Applied Sciences, Department of Health, Switzerland., Langeskov-Christensen M; Exercise Biology, Department of Public Health, Aarhus University, Denmark; Department of Neurology, Viborg Regional Hospital, Denmark. Electronic address: https://twitter.com/LangekovMartin., Zimmer P; Division of Performance and Health, Institute for Sport and Sport Science, Technical University Dortmund, Germany. Electronic address: https://twitter.com/P_Zimmer., Hvid LG; Exercise Biology, Department of Public Health, Aarhus University, Denmark; The Danish MS Hospitals, Ry and Haslev, Denmark. Electronic address: https://twitter.com/HvidLars.
Jazyk: angličtina
Zdroj: Journal of science and medicine in sport [J Sci Med Sport] 2024 Jan; Vol. 27 (1), pp. 10-15. Date of Electronic Publication: 2023 Oct 18.
DOI: 10.1016/j.jsams.2023.10.009
Abstrakt: Objectives: Cardiorespiratory fitness (measured as peak oxygen uptake; V̇O 2peak ) is a well-established health predictor in the general population and in persons with multiple sclerosis (pwMS). We aimed to investigate differences in V̇O 2peak between age groups and the prevalence of V̇O 2peak impairments across the adult lifespan in pwMS compared to age- and sex-matched healthy controls (HC).
Design: Cross-sectional study.
Methods: Data from 469 pwMS (EDSS range 1.0-7.0), who carried out graded cardiopulmonary exercise testing during their rehabilitation stay at the Valens clinic from 07/2010 to 10/2022, were retrospectively analyzed. Data from 21,063 HC were extracted from previously published studies containing normative reference values.
Results: With advanced age (i.e., across age groups), a continuous deterioration of V̇O 2peak was observed in both pwMS and HC. Within all age groups, V̇O 2peak was reduced in pwMS compared to HC with deficits ranging from 29 % to 40 % for females (p < .05), and from 30 % to 41 % for males (p < .05). However, no age ∗ group interaction was observed in neither males (p = .626) nor females (p = .557). With V̇O 2peak impairments defined as values below the 5th percentile of HC, a high prevalence was observed in pwMS, with values ranging from 48 % to 100 % across age groups.
Conclusions: The present data provide evidence for a parallel deterioration of V̇O 2peak in pwMS and matched controls with advancing age, coinciding with a high prevalence of impairments in V̇O 2peak already present in young adulthood in pwMS. Understanding the extent of impairments as well as the age trajectories of cardiorespiratory fitness in pwMS is crucial for designing optimal rehabilitative and preventive interventions.
Competing Interests: Declaration of interest statement MLS, JB, MLC and PZ have no competing interest to declare. LGH has received travel grants and/or teaching honorary from Biogen and Sanofi Genzyme, yet unrelated to the present study.
(Copyright © 2023 Sports Medicine Australia. Published by Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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