Role of bronchial hyperresponsiveness in patients with obstructive sleep apnea with asthma-like symptoms.
| Autor: | Sano A; Department of Respiratory Medicine and Allergology, Kindai University Faculty of Medicine, Osaka, Japan., Kozuka T; Department of Radiology, Kindai University Faculty of Medicine, Osaka, Japan., Watatani N; Department of Respiratory Medicine and Allergology, Kindai University Faculty of Medicine, Osaka, Japan., Kunita Y; Department of Respiratory Medicine and Allergology, Kindai University Faculty of Medicine, Osaka, Japan., Kawabata Y; Department of Respiratory Medicine and Allergology, Kindai University Faculty of Medicine, Osaka, Japan., Gose K; Department of Respiratory Medicine and Allergology, Kindai University Faculty of Medicine, Osaka, Japan., Shirahase K; Department of Respiratory Medicine and Allergology, Kindai University Faculty of Medicine, Osaka, Japan., Yoshikawa K; Department of Respiratory Medicine and Allergology, Kindai University Faculty of Medicine, Osaka, Japan., Yamazaki R; Department of Respiratory Medicine and Allergology, Kindai University Faculty of Medicine, Osaka, Japan., Nishikawa Y; Department of Respiratory Medicine and Allergology, Kindai University Faculty of Medicine, Osaka, Japan., Omori T; Department of Respiratory Medicine and Allergology, Kindai University Faculty of Medicine, Osaka, Japan., Nishiyama O; Department of Respiratory Medicine and Allergology, Kindai University Faculty of Medicine, Osaka, Japan., Iwanaga T; Center for General Medical Education and Clinical Training, Kindai University Hospital, Osaka, Japan., Sano H; Department of Respiratory Medicine and Allergology, Kindai University Faculty of Medicine, Osaka, Japan., Haraguchi R; Department of Respiratory Medicine and Allergology, Kindai University Faculty of Medicine, Osaka, Japan., Tohda Y; Kindai University Hospital, Osaka, Japan., Matsumoto H; Department of Respiratory Medicine and Allergology, Kindai University Faculty of Medicine, Osaka, Japan. Electronic address: hmatsumoto@med.kindai.ac.jp. |
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| Jazyk: | angličtina |
| Zdroj: | Allergology international : official journal of the Japanese Society of Allergology [Allergol Int] 2024 Apr; Vol. 73 (2), pp. 231-235. Date of Electronic Publication: 2023 Nov 10. |
| DOI: | 10.1016/j.alit.2023.10.006 |
| Abstrakt: | Background: Obstructive sleep apnea (OSA) is one of the major co-morbidities and aggravating factors of asthma. In OSA-complicated asthma, obesity, visceral fat, and systemic inflammation are associated with its severity, but the role of bronchial hyperresponsiveness (BHR) is unclear. We investigated the involvement of BHR and mediastinal fat width, as a measure of visceral fat, with OSA severity in patients with OSA and asthma-like symptoms. Methods: Patients with OSA who underwent BHR test and chest computed tomography scan for asthma-like symptoms were retrospectively enrolled. We evaluated the relationship between apnea-hypopnea index (AHI) and PC Results: OSA patients with BHR (n = 29) showed more obstructive airways and frequent low arousal threshold and lower mediastinal fat width, and tended to show fewer AHI than those without BHR (n = 25). In the overall analysis, mediastinal fat width was significantly positively correlated with AHI, which was significant even after adjustment with age and gender. This was especially significant in patients without BHR, while in OSA patients with BHR, there were significant negative associations between apnea index and airflow limitation, and hypopnea index and PC Conclusions: Risk factors for greater AHI differed depending on the presence or absence of BHR in OSA patients with asthma-like symptoms. In the presence of BHR, severity of asthma may determine the severity of concomitant OSA. (Copyright © 2023 Japanese Society of Allergology. Published by Elsevier B.V. All rights reserved.) |
| Databáze: | MEDLINE |
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