Diminished Adaptation, Satisfaction, and Neural Responses to Advantageous Social Signals in Anorexia Nervosa and Bulimia Nervosa.

Autor: Luo Y; Shanghai Key Laboratory of Mental Health and Psychological Crisis Intervention, School of Psychology and Cognitive Science, East China Normal University, Shanghai, China; Fralin Biomedical Research Institute, Virginia Tech, Roanoke, Virginia., Pluta D; Department of Statistics, Rice University, Houston, Texas., Brodrick BB; Department of Psychiatry, University of Texas at Southwestern Medical School, Dallas, Texas., Palka JM; Department of Psychiatry, University of Texas at Southwestern Medical School, Dallas, Texas., McCoy J; Department of Psychiatry, University of Texas at Southwestern Medical School, Dallas, Texas., Lohrenz T; Fralin Biomedical Research Institute, Virginia Tech, Roanoke, Virginia., Gu X; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York; Center for Computational Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York., Vannucci M; Department of Statistics, Rice University, Houston, Texas., Montague PR; Fralin Biomedical Research Institute, Virginia Tech, Roanoke, Virginia; Department of Physics, Virginia Tech, Blacksburg, Virginia; Virginia Tech-Wake Forest School of Biomedical Engineering and Mechanics, Blacksburg, Virginia., McAdams CJ; Department of Psychiatry, University of Texas at Southwestern Medical School, Dallas, Texas. Electronic address: Carrie.McAdams@UTSouthwestern.edu.
Jazyk: angličtina
Zdroj: Biological psychiatry. Cognitive neuroscience and neuroimaging [Biol Psychiatry Cogn Neurosci Neuroimaging] 2024 Mar; Vol. 9 (3), pp. 305-313. Date of Electronic Publication: 2023 Nov 10.
DOI: 10.1016/j.bpsc.2023.10.010
Abstrakt: Background: Development and recurrence of 2 eating disorders (EDs), anorexia nervosa and bulimia nervosa, are frequently associated with environmental stressors. Neurobehavioral responses to social learning signals were evaluated in both EDs.
Methods: Women with anorexia nervosa (n = 25), women with bulimia nervosa (n = 30), or healthy comparison women (n = 38) played a neuroeconomic game in which the norm shifted, generating social learning signals (norm prediction errors [NPEs]) during a functional magnetic resonance imaging scan. A Bayesian logistic regression model examined how the probability of offer acceptance depended on cohort, block, and NPEs. Rejection rates, emotion ratings, and neural responses to NPEs were compared across groups.
Results: Relative to the comparison group, both ED cohorts showed less adaptation (p = .028, η p 2  = 0.060), and advantageous signals (positive NPEs) led to higher rejection rates (p = .014, η p 2  = 0.077) and less positive emotion ratings (p = .004, η p 2  = 0.111). Advantageous signals increased neural activations in the orbitofrontal cortex for the comparison group but not for women with anorexia nervosa (p = .018, d = 0.655) or bulimia nervosa (p = .043, d = 0.527). More severe ED symptoms were associated with decreased activation of dorsomedial prefrontal cortex for advantageous signals.
Conclusions: Diminished neural processing of advantageous social signals and impaired norm adaptation were observed in both anorexia nervosa and bulimia nervosa, while no differences were found for disadvantageous social signals. Development of neurocognitive interventions to increase responsivity to advantageous social signals could augment current treatments, potentially leading to improved clinical outcomes for EDs.
(Copyright © 2023 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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