Comparative Analysis of Symptomatology in Hospitalized Children with RSV, COVID-19, and Influenza Infections.

Autor: Balas WM; Department of Paediatrics and Neonatology with Allergology Center, the National Institute of Medicine of the Ministry of the Interior and Administration, Warsaw, Poland., Śliwczyński A; Health Public Department, The National Institute of Medicine of the Ministry of the Interior and Administration, Warsaw, Poland., Olszewski P; Faculty of Medicine, Łazarski University, Warsaw, Poland., Gołębiak I; Faculty of Medicine, Łazarski University, Warsaw, Poland., Sybilski AJ; Department of Paediatrics and Neonatology with Allergology Center, The National Institute of Medicine of the Ministry of the Interior and Administration, Warsaw, Poland.; Second Department of Paediatrics, Centre of Postgraduate Medical Education, Warsaw, Poland.
Jazyk: angličtina
Zdroj: Medical science monitor : international medical journal of experimental and clinical research [Med Sci Monit] 2023 Nov 11; Vol. 29, pp. e941229. Date of Electronic Publication: 2023 Nov 11.
DOI: 10.12659/MSM.941229
Abstrakt: BACKGROUND The clinical course of respiratory syncytial virus (RSV), SARS-CoV-2, and influenza infections comprises many non-specific symptoms, which makes diagnosis difficult. The aim of this study was to retrospectively analyze the symptomatology of these infections in children and to search for correlations between them. MATERIAL AND METHODS A total of 121 children with a positive RSV (n=61), influenza (n=31), or SARS-CoV-2 (n=29) antigen test were enrolled in this retrospective analysis. Children were aged up to 71 months (median, 8 months). The collected data were collated by performing statistical analysis using the chi-square test and comparing the results using OR (odds ratio) and 95%CI (confidence interval). RESULTS There was a higher risk of fever in children with influenza than in those with RSV. Patients infected with RSV had a higher risk of nasal blockage than those with SARS-CoV-2. Dyspnea was more common in RSV infection than in influenza. Severe, sleep-awakening cough was more frequent in children with RSV than in those with COVID-19. Influenza was more prevalent in children aged >24 months than in those aged 7-24 months. RSV-infected children had a higher risk of numerous auscultatory changes compared to those with SARS-CoV-2. In the case of RSV infection, symptoms requiring hospitalization occurred later than in SARS-CoV-2 infection. CONCLUSIONS Children aged >24 months were at higher risk of contracting influenza. Numerous auscultatory changes, nasal blockage, and dyspnea were more common in children with RSV. There was a higher risk of dyspnea in children with RSV. Fever was more frequent in children with influenza. However, none of the symptoms clearly indicated the etiology of the infection.
Databáze: MEDLINE