Impact of age on the outcomes of Takotsubo syndrome.

Autor: Simon Frances B; MedStar Cardiovascular Research Network, NW, Washington, DC, USA., Sans-Roselló J; Department of Cardiology, Parc Taulí Hospital Universitari, Sabadell, Barcelona, Spain. Electronic address: jordisansrosello@hotmail.com., Brugaletta S; Hospital Clinic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain., Cerrato E; Interventional Cardiology Unit. San Luigi Gonzaga University Hospital, Orbassano, Italy and Infermi Hospital, Rivoli (Turin), Italy., Alfonso F; Section of Interventional Cardiology, Department of Cardiology, Hospital Universitario de La Princesa, CIBERCV, IIS-IP, Universidad Autónoma de Madrid, Madrid, Spain., Gonzalo N; Interventional Cardiology, Hospital Clinico San Carlos, IdISSC, Universidad Complutense, Madrid, Spain., Amat-Santos IJ; CIVERCV, Cardiology Department, University Clínic Hospital, Valladolid, Spain., Fernández-Peregrina E; Section of Interventional Cardiology, Department of Cardiology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain., Teira Calderón A; Section of Interventional Cardiology, Department of Cardiology, Hospital Universitari i Politecnic La Fe, Valencia, Spain., Varghese JJ; MedStar Cardiovascular Research Network, NW, Washington, DC, USA., Garg M; MedStar Cardiovascular Research Network, NW, Washington, DC, USA., García-García HM; Section of Interventional Cardiology, MedStar Washington Hospital Center, EB 521, 110 Irving St NW, Washington, DC 20010, USA. Electronic address: hect2701@gmail.com.
Jazyk: angličtina
Zdroj: Cardiovascular revascularization medicine : including molecular interventions [Cardiovasc Revasc Med] 2024 Apr; Vol. 61, pp. 44-51. Date of Electronic Publication: 2023 Nov 03.
DOI: 10.1016/j.carrev.2023.10.018
Abstrakt: Background: The impact on age on the short-term and long-term prognosis in patients with Takotsubo syndrome (TTS) is unclear. We aimed to evaluate whether age has prognostic implications during hospital stay and long-term follow-up of TTS patients.
Methods: 688 consecutive patients were admitted for TTS in 7 tertiary centers from January-2008 to June-2021. We divided our cohort into two groups (patients <75 years and ≥75 years). Clinical, analytical, and hemodynamic variables as well as in-hospital management were registered and compared between groups. Mortality rates during hospital stay and follow-up were assessed. Adverse cardiovascular events (ACE) were defined as the composite of cardiovascular death, heart failure event, acute myocardial infarction, stroke and symptomatic arrhythmia.
Results: Median age was 74.7 years and 49.4 % were ≥75 years. 86.9 % were women and 22.3 % were secondary forms of TTS. In-hospital mortality was 3.6 % (1.5 % cardiovascular). Median clinical follow-up was 4.3 years. Mortality during the follow-up period was 23 % (5.0 % cardiovascular) while ACE were 22.5 %, mainly due to heart failure events. Kaplan-Meier curves showed both higher rates of mortality and ACE in ≥75 years group (30.2 % vs 15.8 %; p < 0.001 and 28.3 % vs 16.7 %; p < 0.001). Age was independently associated with higher rates of overall mortality and ACE in patients with TTS. Hypertension, absence of sinus rhythm, Killip class > I and a more impaired coronary microvascular resistance were also associated to ACE in TTS patients.
Conclusions: Advanced age was associated with higher rate of overall mortality and ACE during long-term follow-up in TTS patients.
Competing Interests: Declaration of competing interest Dr. Hector M. Garcia-Garcia reports the following institutional grant support: Biotronik, Boston Scientific, Medtronic, Abbott, Neovasc, Shockwave, Phillips and Corflow. The following is the supplementary data related to this article. Supplementary data to this article can be found online at https://doi.org/10.1016/j.carrev.2023.10.018.
(Copyright © 2023 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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