| Autor: |
Nicolucci C; Medical School, São Francisco University, Bragança Paulista, São Paulo, Brazil.; Postgraduate Program in Health Sciences, Bragança Paulista, São Paulo, Brazil., Padovani M; Medical School, São Francisco University, Bragança Paulista, São Paulo, Brazil., Rodrigues FC; Psychiatry Medical Residency Program, São Francisco University Hospital, Bragança Paulista, São Paulo, Brazil., Fritsch LN; Psychiatry Medical Residency Program, São Francisco University Hospital, Bragança Paulista, São Paulo, Brazil., Santos AC; Institute of Biophysics of University of Coimbra, Coimbra, Portugal.; Institute for Clinical and Biomedical Research (iCBR/Cibb), University of Coimbra, Coimbra, Portugal.; Faculty of Medicine, University of Coimbra, Coimbra, Portugal., Priolli DG; Department of Coloproctology, Federal University of São Paulo (UNIFESP), São Paulo, Brazil.; Medical School from Pitágoras Faculty, Codó, Maranhão, Brazil., Sciani JM; Postgraduate Program in Health Sciences, Bragança Paulista, São Paulo, Brazil.; Laboratory of Natural Products, Bragança Paulista, São Paulo, Brazil. |
| Abstrakt: |
Given the current increase in mental and neurological disorders, there is an urgent need to develop alternative treatments for patients. Flavonoids exhibit diverse biological activities, including antioxidant, anti-inflammatory and neuroprotective, and has been considered potential therapies for central nervous system diseases, such as Alzheimer's disease, Parkinson's disease, drug addiction, and stroke. Studies have shown that flavonoids protect neurons from oxidative stress, reduce inflammation, improve brain blood flow and enhance cognitive function. Moreover, its modulation of neurotransmission, such as GABAergic, dopaminergic, serotoninergic, and noradrenergic, has been studied for the treatment of mental disorders that require sedative effects, antidepressants, sleep inducers and anxiety reduction. Although more research is needed to fully understand the mechanisms and potential benefits of these compounds, the use of flavonoids for neurological diseases is a promising avenue for future research and development. This review focuses on major flavonoid subclasses and their applications in central nervous system disorders. |
