Cortical excitation/inhibition ratios in patients with major depression treated with electroconvulsive therapy: an EEG analysis.

Autor: Stuiver S; Technical Medical Centre, Faculty of Science and Technology, Clinical Neurophysiology, University of Twente, Hallenweg 15, 7522NB, Enschede, The Netherlands. sstuiver@rijnstate.nl.; Department of Psychiatry, Rijnstate Hospital, Wagnerlaan 55, P.O. Box 9555, 6815AD, Arnhem, The Netherlands. sstuiver@rijnstate.nl., Pottkämper JCM; Technical Medical Centre, Faculty of Science and Technology, Clinical Neurophysiology, University of Twente, Hallenweg 15, 7522NB, Enschede, The Netherlands.; Department of Psychiatry, Rijnstate Hospital, Wagnerlaan 55, P.O. Box 9555, 6815AD, Arnhem, The Netherlands.; Department of Neurology, Rijnstate Hospital, Wagnerlaan 55, 6815AD, Arnhem, The Netherlands., Verdijk JPAJ; Technical Medical Centre, Faculty of Science and Technology, Clinical Neurophysiology, University of Twente, Hallenweg 15, 7522NB, Enschede, The Netherlands.; Department of Psychiatry, Rijnstate Hospital, Wagnerlaan 55, P.O. Box 9555, 6815AD, Arnhem, The Netherlands., Ten Doesschate F; Department of Psychiatry, Rijnstate Hospital, Wagnerlaan 55, P.O. Box 9555, 6815AD, Arnhem, The Netherlands., Aalbregt E; Department of Surgery, Amsterdam UMC Location Vumc, Boelelaan 1108, 1081HZ, Amsterdam, The Netherlands., van Putten MJAM; Technical Medical Centre, Faculty of Science and Technology, Clinical Neurophysiology, University of Twente, Hallenweg 15, 7522NB, Enschede, The Netherlands., Hofmeijer J; Technical Medical Centre, Faculty of Science and Technology, Clinical Neurophysiology, University of Twente, Hallenweg 15, 7522NB, Enschede, The Netherlands.; Department of Neurology, Rijnstate Hospital, Wagnerlaan 55, 6815AD, Arnhem, The Netherlands., van Waarde JA; Department of Psychiatry, Rijnstate Hospital, Wagnerlaan 55, P.O. Box 9555, 6815AD, Arnhem, The Netherlands.
Jazyk: angličtina
Zdroj: European archives of psychiatry and clinical neuroscience [Eur Arch Psychiatry Clin Neurosci] 2024 Jun; Vol. 274 (4), pp. 793-802. Date of Electronic Publication: 2023 Nov 10.
DOI: 10.1007/s00406-023-01708-5
Abstrakt: Electroconvulsive therapy (ECT) is an effective treatment for major depression, but its working mechanisms are poorly understood. Modulation of excitation/inhibition (E/I) ratios may be a driving factor. Here, we estimate cortical E/I ratios in depressed patients and study whether these ratios change over the course of ECT in relation to clinical effectiveness. Five-minute resting-state electroencephalography (EEG) recordings of 28 depressed patients were recorded before and after their ECT course. Using a novel method based on critical dynamics, functional E/I (fE/I) ratios in the frequency range of 0.5-30 Hz were estimated in frequency bins of 1 Hz for the whole brain and for pre-defined brain regions. Change in Hamilton Depression Rating Scale (HDRS) score was used to estimate clinical effectiveness. To account for test-retest variability, repeated EEG recordings from an independent sample of 31 healthy controls (HC) were included. At baseline, no differences in whole brain and regional fE/I ratios were found between patients and HC. At group level, whole brain and regional fE/I ratios did not change over the ECT course. However, in responders, frontal fE/I ratios in the frequencies 12-28 Hz increased significantly (p FDR  < 0.05 [FDR = false discovery rate]) over the ECT course. In non-responders and HC, no changes occurred over time. In this sample, frontal fE/I ratios increased over the ECT course in relation to treatment response. Modulation of frontal fE/I ratios may be an important mechanism of action of ECT.
(© 2023. The Author(s).)
Databáze: MEDLINE
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