Signaling Pathways Controlling Axonal Wrapping in Drosophila .

Autor: Baldenius M; Institute for Neuro- and Behavioral Biology, Faculty of Biology, University of Münster, Röntgenstraße 16, D-48149 Münster, Germany., Kautzmann S; Institute for Neuro- and Behavioral Biology, Faculty of Biology, University of Münster, Röntgenstraße 16, D-48149 Münster, Germany., Nanda S; Institute for Neuro- and Behavioral Biology, Faculty of Biology, University of Münster, Röntgenstraße 16, D-48149 Münster, Germany., Klämbt C; Institute for Neuro- and Behavioral Biology, Faculty of Biology, University of Münster, Röntgenstraße 16, D-48149 Münster, Germany.
Jazyk: angličtina
Zdroj: Cells [Cells] 2023 Oct 31; Vol. 12 (21). Date of Electronic Publication: 2023 Oct 31.
DOI: 10.3390/cells12212553
Abstrakt: The rapid transmission of action potentials is an important ability that enables efficient communication within the nervous system. Glial cells influence conduction velocity along axons by regulating the radial axonal diameter, providing electrical insulation as well as affecting the distribution of voltage-gated ion channels. Differentiation of these wrapping glial cells requires a complex set of neuron-glia interactions involving three basic mechanistic features. The glia must recognize the axon, grow around it, and eventually arrest its growth to form single or multiple axon wraps. This likely depends on the integration of numerous evolutionary conserved signaling and adhesion systems. Here, we summarize the mechanisms and underlying signaling pathways that control glial wrapping in Drosophila and compare those to the mechanisms that control glial differentiation in mammals. This analysis shows that Drosophila is a beneficial model to study the development of even complex structures like myelin.
Databáze: MEDLINE
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