Association Between a First-Degree Family History and Self-Reported Personal History of Obesity, Diabetes, and Heart and Blood Conditions: Results From the All of Us Research Program.

Autor: Rasooly D; Division of Blood Disorders and Public Health Genomics National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention Atlanta GA USA., Moonesinghe R; Division of Blood Disorders and Public Health Genomics National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention Atlanta GA USA., Littrell K; Division of Blood Disorders and Public Health Genomics National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention Atlanta GA USA., Hull L; Division of General Internal Medicine, Massachusetts General Hospital Boston MA USA.; Department of Medicine Harvard Medical School Boston MA USA., Khoury MJ; Division of Blood Disorders and Public Health Genomics National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention Atlanta GA USA.
Jazyk: angličtina
Zdroj: Journal of the American Heart Association [J Am Heart Assoc] 2023 Nov 21; Vol. 12 (22), pp. e030779. Date of Electronic Publication: 2023 Nov 10.
DOI: 10.1161/JAHA.123.030779
Abstrakt: Background: Family history reflects the complex interplay of genetic susceptibility and shared environmental exposures and is an important risk factor for obesity, diabetes, and heart and blood conditions (ODHB). However, the overlap in family history associations between various ODHBs has not been quantified.
Methods and Results: We assessed the association between a self-reported family history of ODHBs and their risk in the adult population (age ≥20 years) of the AoU (All of Us) Research Program, a longitudinal cohort study of diverse participants across the United States. We conducted a family history-wide association study to systematically assess the association of a first-degree family history of 15 ODHBs in AoU. We performed stratified analyses based on racial and ethnic categories, education, household income and gender minority status, and quantified associations by type of affected relatives. Of 125 430 participants, 76.8% reported a first-degree family history of any ODHB, most commonly hypertension (n=64 982, 51.8%), high cholesterol (49 753, 39.7%), and heart attack (29 618, 23.6%). We use the FamWAS method to estimate 225 familial associations among 15 ODHBs. The results include overlapping associations between family history of different types of cardiometabolic conditions (such as type 2 diabetes and coronary artery disease), and their risk factors (obesity, hypertension), where adults with a family history of 1 ODHB exhibited 1.1 to 5.6 times (1.5, on average) the odds of having a different ODHB.
Conclusions: Our findings inform the utility of family history data as a risk assessment and screening tool for the prevention of ODHBs and to provide additional insights into shared risk factors and pathogenic mechanisms.
Databáze: MEDLINE
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