Predicting ADHD in alcohol dependence using polygenic risk scores for ADHD.

Autor: Patel KHS; Molecular Psychiatry Laboratory, Division of Psychiatry, University College London, London, UK., Walters GB; deCODE genetics/Amgen, Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavík, Iceland., Stefánsson H; deCODE genetics/Amgen, Reykjavik, Iceland., Stefánsson K; deCODE genetics/Amgen, Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavík, Iceland., Degenhardt F; Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, LVR Klinikum Essen, University of Duisburg-Essen, Essen, Germany.; Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital, Bonn, Germany., Nothen M; Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital, Bonn, Germany., Van Der Veen T; Molecular Psychiatry Laboratory, Division of Psychiatry, University College London, London, UK., Demontis D; Department of Biomedicine-Human Genetics, Aarhus University, Aarhus, Denmark.; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark.; Center for Genomics and Personalized Medicine, Aarhus, Denmark., Borglum A; Department of Biomedicine-Human Genetics, Aarhus University, Aarhus, Denmark.; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark.; Center for Genomics and Personalized Medicine, Aarhus, Denmark., Kristiansen M; University College London Genomics, Institute of Child Health, University College London, London, UK., Bass NJ; Molecular Psychiatry Laboratory, Division of Psychiatry, University College London, London, UK., McQuillin A; Molecular Psychiatry Laboratory, Division of Psychiatry, University College London, London, UK.
Jazyk: angličtina
Zdroj: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics [Am J Med Genet B Neuropsychiatr Genet] 2024 Jun; Vol. 195 (4), pp. e32967. Date of Electronic Publication: 2023 Nov 09.
DOI: 10.1002/ajmg.b.32967
Abstrakt: Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder with a high degree of comorbidity, including substance misuse. We aimed to assess whether ADHD polygenic risk scores (PRS) could predict ADHD diagnosis in alcohol dependence (AD). ADHD PRS were generated for 1223 AD subjects with ADHD diagnosis information and 1818 healthy controls. ADHD PRS distributions were compared to evaluate the differences between healthy controls and AD cases with and without ADHD. We found increased ADHD PRS means in the AD cohort with ADHD (mean 0.30, standard deviation (SD) 0.92; p = 3.9 × 10 -6 ); and without ADHD (mean - 0.00, SD 1.00; p = 5.2 × 10 -5 ) compared to the healthy control subjects (mean - 0.17, SD 0.99). The ADHD PRS means differed within the AD group with a higher ADHD PRS mean in those with ADHD, odds ratio (OR) 1.34, confidence interval (CI) 1.10 to 1.65; p = 0.002. This study showed a positive relationship between ADHD PRS and risk of ADHD in individuals with co-occurring AD indicating that ADHD PRS may have utility in identifying individuals that are at a higher or lower risk of ADHD. Further larger studies need to be conducted to confirm the reliability of the results before ADHD PRS can be considered as a robust biomarker for diagnosis.
(© 2023 The Authors. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics published by Wiley Periodicals LLC.)
Databáze: MEDLINE
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