Progesterone activation of β 1 -containing BK channels involves two binding sites.
Autor: | North KC; Department of Pharmacology, Addiction Science, and Toxicology, College of Medicine, The University of Tennessee Health Science Center, Memphis, TN, 38103, USA., Shaw AA; Department of Pharmacology, Addiction Science, and Toxicology, College of Medicine, The University of Tennessee Health Science Center, Memphis, TN, 38103, USA., Bukiya AN; Department of Pharmacology, Addiction Science, and Toxicology, College of Medicine, The University of Tennessee Health Science Center, Memphis, TN, 38103, USA., Dopico AM; Department of Pharmacology, Addiction Science, and Toxicology, College of Medicine, The University of Tennessee Health Science Center, Memphis, TN, 38103, USA. adopico@uthsc.edu. |
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Jazyk: | angličtina |
Zdroj: | Nature communications [Nat Commun] 2023 Nov 09; Vol. 14 (1), pp. 7248. Date of Electronic Publication: 2023 Nov 09. |
DOI: | 10.1038/s41467-023-42827-w |
Abstrakt: | Progesterone (≥1 µM) is used in recovery of cerebral ischemia, an effect likely contributed to by cerebrovascular dilation. The targets of this progesterone action are unknown. We report that micromolar (µM) progesterone activates mouse cerebrovascular myocyte BK channels; this action is lost in β (© 2023. The Author(s).) |
Databáze: | MEDLINE |
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