Quantitative 4D flow MRI-derived thoracic aortic normal values of 2D flow MRI parameters in healthy volunteers.

Autor:	Ebel S; Diagnostic and Interventional Radiology, Leipzig University, Leipzig, Germany., Kühn A; Diagnostic and Interventional Radiology, Leipzig Heart Centre University Hospital, Leipzig, Germany., Köhler B; Simulation and Graphics, Otto von Guericke Universität Magdeburg, Germany., Behrendt B; Simulation and Graphics, Otto von Guericke Universität Magdeburg, Germany., Riekena B; Diagnostic and Interventional Radiology, Leipzig Heart Centre University Hospital, Leipzig, Germany., Preim B; Simulation and Graphics, Otto von Guericke Universität Magdeburg, Germany., Denecke T; Diagnostic and Interventional Radiology, Leipzig University, Leipzig, Germany., Grothoff M; Diagnostic and Interventional Radiology, Leipzig Heart Centre University Hospital, Leipzig, Germany., Gutberlet M; Diagnostic and Interventional Radiology, Leipzig Heart Centre University Hospital, Leipzig, Germany.
Jazyk:	angličtina
Zdroj:	RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin [Rofo] 2024 Mar; Vol. 196 (3), pp. 273-282. Date of Electronic Publication: 2023 Nov 09.
DOI:	10.1055/a-2175-4165
Abstrakt:	Purpose:  To utilize 4 D flow MRI to acquire normal values of "conventional 2 D flow MRI parameters" in healthy volunteers in order to replace multiple single 2 D flow measurements with a single 4 D flow acquisition. Materials and Methods:  A kt-GRAPPA accelerated 4 D flow sequence was used. Flow volumes were assessed by forward (FFV), backward (BFV), and net flow volumes (NFV) [ml/heartbeat] and flow velocities by axial (VAX) and absolute velocity (VABS) [m/s] in 116 volunteers (58 females, 43 ± 13 years). The aortic regurgitant fraction (RF) was calculated. Results:  The sex-neutral mean FFV, BFV, NFV, and RF in the ascending aorta were 93.5 ± 14.8, 3.6 ± 2.8, 89.9 ± 0.6 ml/heartbeat, and 3.9 ± 2.9 %, respectively. Significantly higher values were seen in males regarding FFV, BFV, NFV and RF, but there was no sex dependency regarding VAX and VABS. The mean maximum VAX was lower (1.01 ± 0.31 m/s) than VABS (1.23 ± 0.35 m/s). We were able to determine normal ranges for all intended parameters. Conclusion:  This study provides quantitative 4 D flow-derived thoracic aortic normal values of 2 D flow parameters in healthy volunteers. FFV, BFV, NFV, and VAX did not differ significantly from single 2 D flow acquisitions and could therefore replace time-consuming multiple single 2 D flow acquisitions. VABS should not be used interchangeably. Key Points:   · 4 D flow MRI can be used to replace 2 D flow MRI measurements.. · The parameter absolute velocities can be assessed by 4 D flow MRI.. · There are sex-dependent differences regarding forward, backward, net aortic blood flow and the aortic valve regurgitant fraction.. Competing Interests: The authors declare that they have no conflict of interest. (Thieme. All rights reserved.)
Databáze:	MEDLINE
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