The association between symptoms of gastroesophageal reflux disease and perceived stress: A countrywide study of Sri Lanka.

Autor: Wickramasinghe N; Department of Physiology, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka., Thuraisingham A; Ministry of Health, Colombo, Sri Lanka., Jayalath A; Ministry of Health, Colombo, Sri Lanka., Wickramasinghe D; Department of Surgery, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka., Samarasekara N; Department of Surgery, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka., Yazaki E; Gastrointestinal Physiology Unit, Barts and The London School of Medicine, London, United Kingdom., Devanarayana NM; Department of Physiology, Faculty of Medicine, University of Kelaniya, Kelaniya, Sri Lanka.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2023 Nov 09; Vol. 18 (11), pp. e0294135. Date of Electronic Publication: 2023 Nov 09 (Print Publication: 2023).
DOI: 10.1371/journal.pone.0294135
Abstrakt: Background/aims: Stress is a known associated factor for gastroesophageal reflux disease (GERD). However, the dynamics between stress and GERD are not fully studied, especially in Sri Lanka. Our objective was to assess it.
Methods: For this cross-sectional descriptive study, 1200 individuals (age ranged 18-70 years, mean 42.7 years [SD 14.4 years], 46.1% males), were recruited using stratified random cluster sampling from all 25 districts of Sri Lanka. An interviewer-administered questionnaire, which included a country-validated GERD symptom screening tool, and the Perceived Stress Scale (PSS), was used to assess GERD symptoms and stress. Probable GERD was defined as those having heartburn and/ or regurgitation at least once per week which is on par with globally accepted criteria. Those who did not fulfill these criteria were considered as controls.
Results: PSS score was higher in those with probable GERD (mean 13.75 [standard deviation (SD) 6.87]) than in controls (mean 10.93 [SD 6.80]), (p <0.001, Mann-Whitney U test). The adjusted odds ratio for GERD symptoms was 1.96 times higher (95% confidence interval 1.50-2.55) in the moderate to high-stress level compared to the low-stress level participants. PSS score correlated significantly with the GERD screening tool score (R 0.242, p <0.001). Heartburn, regurgitation, chest pain, cough, and burping were significantly frequent in those with moderate to high-stress levels (p <0.001). Those with higher stress scores were more likely to use acid-lowering drugs (p = 0.006).
Conclusions: Individuals exposed to higher levels of stress are more likely to have GERD symptoms. Therefore, stress reduction should be an important part of GERD symptom management.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2023 Wickramasinghe et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
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