Executive summary: Guidelines of care for the management of atopic dermatitis in adults with phototherapy and systemic therapies.

Autor: Davis DMR; Departments of Dermatology and Pediatrics, Mayo Clinic, Rochester, Minnesota., Drucker AM; Division of Dermatology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada; Women's College Research Institute, Women's College Hospital, Toronto, Ontario, Canada., Alikhan A; Department of Dermatology, Sutter Medical Foundation, Sacramento, California., Bercovitch L; Department of Dermatology, Warren Alpert Medical School of Brown University, Providence, Rhode Island., Cohen DE; The Ronald O. Perelman Department of Dermatology, New York University Grossman School of Medicine, New York, New York., Darr JM; Department of Pediatrics, Pediatric Behavioral Health, National Jewish Health, Denver, Colorado., Eichenfield LF; Departments of Dermatology and Pediatrics, University of California San Diego and Rady Children's Hospital San Diego, San Diego, California., Frazer-Green L; American Academy of Dermatology, Rosemont, Illinois. Electronic address: lfrazer-green@aad.org., Paller AS; Departments of Dermatology and Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois., Schwarzenberger K; Department of Dermatology, Oregon Health and Science University, Portland, Oregon., Silverberg JI; Department of Dermatology, The George Washington University School of Medicine and Health Sciences, Washington, District of Columbia., Singh AM; Departments of Pediatrics, Dermatology and Medical Microbiology/Immunology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin., Wu PA; Department of Dermatology, University of California, Davis, Sacramento, California., Sidbury R; Division of Dermatology, Department of Pediatrics, University of Washington School of Medicine and Seattle Children's Hospital, Seattle, Washington.
Jazyk: angličtina
Zdroj: Journal of the American Academy of Dermatology [J Am Acad Dermatol] 2024 Feb; Vol. 90 (2), pp. 342-345. Date of Electronic Publication: 2023 Nov 07.
DOI: 10.1016/j.jaad.2023.08.103
Abstrakt: Background: The summarized guidelines update the 2014 recommendations for the management of AD with phototherapy and systemic therapies.
Methods: A multidisciplinary workgroup conducted a systematic review and applied the GRADE approach for assessing the certainty of the evidence and formulating and grading recommendations.
Results: The workgroup developed 11 recommendations on the management of AD in adults with phototherapy and systemic therapies, including biologics, oral Janus Kinase inhibitors, and other immunomodulatory medications.
Conclusions: The evidence supported strong recommendations for the use of dupilumab, tralokinumab, abrocitinib, baricitinib, and upadacitinib and conditional recommendations in favor of using phototherapy, azathioprine, cyclosporine, methotrexate, and mycophenolate, and against the use of systemic corticosteroids.
Competing Interests: Conflict of interest The American Academy of Dermatology (AAD) strives to produce clinical guidelines that reflect the best available evidence supplemented with the judgment of expert clinicians. Significant efforts are taken to minimize the potential for conflicts of interest to influence guideline content. The management of conflict of interest for this guideline complies with the Council of Medical Specialty Societies' Code of Interactions with Companies. Funding of guideline production by medical or pharmaceutical entities is prohibited, full disclosure is obtained and evaluated for all guideline contributors throughout the guideline development process, and recusal is used to manage identified relationships. The AAD conflict of interest policy summary may be viewed at www.aad.org.
(Copyright © 2023 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: