Multicompartment Micro- and Nanoparticles Using Supramolecular Assembly of Core-Shell Bottlebrush Polymers.

Autor: Phan QT; Faculty of Pharmacy, Université de Montréal, 2940 Chemin de Polytechnique, Montréal, Québec H3T 1J4, Canada., Zhang H; Faculty of Pharmacy, Université de Montréal, 2940 Chemin de Polytechnique, Montréal, Québec H3T 1J4, Canada., Pham DA; Faculty of Pharmacy, Université de Montréal, 2940 Chemin de Polytechnique, Montréal, Québec H3T 1J4, Canada., Rabanel JM; Faculty of Pharmacy, Université de Montréal, 2940 Chemin de Polytechnique, Montréal, Québec H3T 1J4, Canada., Filippini A; Faculty of Pharmacy, Université de Montréal, 2940 Chemin de Polytechnique, Montréal, Québec H3T 1J4, Canada., Boffito D; Department of Chemical Engineering, Polytechnique Montréal, 2500 Chemin de Polytechnique, Montréal, Québec H3C 3A7, Canada., Banquy X; Faculty of Pharmacy, Université de Montréal, 2940 Chemin de Polytechnique, Montréal, Québec H3T 1J4, Canada.; Biomedical Engineering Institute, Université de Montréal, 2940 Chemin de Polytechnique, Montréal, Québec H3T 1J4, Canada.; Chemistry Department, Faculty of Arts and Sciences, Université de Montréal, 2940 Chemin de Polytechnique, Montréal, Québec H3T 1J4, Canada.
Jazyk: angličtina
Zdroj: ACS macro letters [ACS Macro Lett] 2023 Nov 21; Vol. 12 (11), pp. 1589-1594. Date of Electronic Publication: 2023 Nov 09.
DOI: 10.1021/acsmacrolett.3c00580
Abstrakt: Multicompartment particles have been produced to date by the self-assembly of linear multiblock polymers. Besides the large diversity of structures that can be obtained with this approach, these are highly sensitive to dilution and environmental factors. Here we show that using core-shell bottlebrush polymers with a hydrophobic polyester core as starting materials it is possible to create compartmentalized particles from the micrometer size down to the molecular scale. These polymers can be used as building blocks to create multicompartment particles and networks via a self-assembly process. The polymers can encapsulate active compounds and slowly degrade in water into polymeric micelles, making them promising materials for drug delivery applications.
Databáze: MEDLINE
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