Early life exposure to broccoli sprouts confers stronger protection against enterocolitis development in an immunological mouse model of inflammatory bowel disease.

Autor:	Holcomb L; Graduate School of Biomedical Sciences and Engineering, University of Maine, Orono, Maine, USA., Holman JM; School of Food and Agriculture, University of Maine, Orono, Maine, USA., Hurd M; Larner College of Medicine, University of Vermont, Burlington, Vermont, USA., Lavoie B; Larner College of Medicine, University of Vermont, Burlington, Vermont, USA., Colucci L; Department of Biology, Husson University, Bangor, Maine, USA., Hunt B; Department of Biology, University of Maine, Orono, Maine, USA., Hunt T; Department of Biology, University of Maine, Orono, Maine, USA., Kinney M; School of Food and Agriculture, University of Maine, Orono, Maine, USA., Pathak J; Graduate School of Biomedical Sciences and Engineering, University of Maine, Orono, Maine, USA., Mawe GM; Larner College of Medicine, University of Vermont, Burlington, Vermont, USA., Moses PL; Larner College of Medicine, University of Vermont, Burlington, Vermont, USA.; Finch Therapeutics, Somerville, Massachusetts, USA., Perry E; Electron Microscopy Laboratory, University of Maine, Orono, Maine, USA., Stratigakis A; School of Pharmacy and Pharmaceutical Sciences, SUNY Binghamton University, Johnson City, New York, USA., Zhang T; School of Pharmacy and Pharmaceutical Sciences, SUNY Binghamton University, Johnson City, New York, USA., Chen G; Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA., Ishaq SL; Graduate School of Biomedical Sciences and Engineering, University of Maine, Orono, Maine, USA., Li Y; Graduate School of Biomedical Sciences and Engineering, University of Maine, Orono, Maine, USA.
Jazyk:	angličtina
Zdroj:	MSystems [mSystems] 2023 Dec 21; Vol. 8 (6), pp. e0068823. Date of Electronic Publication: 2023 Nov 09.
DOI:	10.1128/msystems.00688-23
Abstrakt:	Importance: To our knowledge, IL-10-KO mice have not previously been used to investigate the interactions of host, microbiota, and broccoli, broccoli sprouts, or broccoli bioactives in resolving symptoms of CD. We showed that a diet containing 10% raw broccoli sprouts increased the plasma concentration of the anti-inflammatory compound sulforaphane and protected mice to varying degrees against disease symptoms, including weight loss or stagnation, fecal blood, and diarrhea. Younger mice responded more strongly to the diet, further reducing symptoms, as well as increased gut bacterial richness, increased bacterial community similarity to each other, and more location-specific communities than older mice on the diet intervention. Crohn's disease disrupts the lives of patients and requires people to alter dietary and lifestyle habits to manage symptoms. The current medical treatment is expensive with significant side effects, and a dietary intervention represents an affordable, accessible, and simple strategy to reduce the burden of symptoms. Competing Interests: The authors declare no conflict of interest.
Databáze:	MEDLINE
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