Inclusion of optic neuritis in dissemination in space improves the performance of McDonald 2017 criteria in Hispanic people with suspected multiple sclerosis.

Autor:	Amezcua L; Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Robers MV; Barrow Neurological Institute, Phoenix, AZ, USA., Soneji D; Neurology and Neuroophthalmology, Sutter East Bay Medical Group, Lafayette, CA, USA., Manouvakhova O; Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Martinez A; Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Islam T; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Jazyk:	angličtina
Zdroj:	Multiple sclerosis (Houndmills, Basingstoke, England) [Mult Scler] 2023 Dec; Vol. 29 (14), pp. 1748-1754. Date of Electronic Publication: 2023 Nov 09.
DOI:	10.1177/13524585231209016
Abstrakt:	Background: Hispanic people compared to White people with multiple sclerosis (MS) are two times more likely to present with optic neuritis (ON). ON in dissemination in space (DIS) after a single attack is not part of the current McDonald 2017 criteria. Objective: To evaluate if adding ON in DIS (ON-modified criteria) improves the performance of the McDonald 2017 criteria in the diagnosis of MS after a single attack of ON. Methods: Retrospective study of 102 patients of Hispanic background. Cases were reviewed between 2017 and 2021. Clinical ON was reported for 35 cases. ON in DIS was verified for 28 patients via MRI, optical coherence tomography, and/or visual evoked potential. We investigated the performance of the McDonald 2017 criteria and ON-modified criteria and calculated sensitivity, specificity, positive and negative predictive values, and accuracy. Results: The ON-modified criteria significantly improved the performance of the McDonald 2017 criteria ( p = 0.003) and identified an additional nine patients. Both sensitivity and accuracy increased from 64% to 74% and 62% to 71%, respectively, while specificity remained unchanged (40% (95% confidence interval (CI): 0.10, 0.70)). Conclusion: This study provides evidence that the inclusion of ON in DIS improved the overall performance of the McDonald 2017 criteria among Hispanic people. Competing Interests: Declaration of conflicting interestsThe author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: L.A. has research support from the National MS Society, NIH NINDS, Bristol Myer Squibb Foundation, Race to Erase MS Foundation, and Biogen Idec. She is a local PI for commercial trials funded by Genentech and Sanofi and Genzyme and receives consulting fees from Biogen Idec, Novartis, Genentech, and EMD Serono. M.V.R. receives research funding from the Robert A. Winn Diversity in Clinical Trials Awards Program founded by the Bristol Myers Squibb Foundation. He has received consulting fees from EMD Serono. D.S. is a local PI for a commercial trial funded by Novartis. O.M., A.M., and T.I. have no disclosures.
Databáze:	MEDLINE
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