Antidiarrheal and antioxidant activities of Ajuga iva (L.) leave extract.

Autor: Ladjimi MH; Laboratory of Integrated Physiology UR11S33, Faculty of Science of Bizerte, University of Carthage, 7021 Jarzouna, Tunisia., Ben Barka Z; Laboratory of Integrated Physiology UR11S33, Faculty of Science of Bizerte, University of Carthage, 7021 Jarzouna, Tunisia., Lahbib K; Laboratory of Heteroatom Organic Chemistry, Department of Chemistry, Faculty of Science of Bizerte, University of Carthage, 7021, Jarzouna, Tunisia., Ben Miled H; Laboratory of Integrated Physiology UR11S33, Faculty of Science of Bizerte, University of Carthage, 7021 Jarzouna, Tunisia., Ben Rhouma K; Laboratory of Integrated Physiology UR11S33, Faculty of Science of Bizerte, University of Carthage, 7021 Jarzouna, Tunisia., Sakly M; Laboratory of Integrated Physiology UR11S33, Faculty of Science of Bizerte, University of Carthage, 7021 Jarzouna, Tunisia., Tebourbi O; Laboratory of Integrated Physiology UR11S33, Faculty of Science of Bizerte, University of Carthage, 7021 Jarzouna, Tunisia.
Jazyk: angličtina
Zdroj: Heliyon [Heliyon] 2023 Oct 21; Vol. 9 (11), pp. e21139. Date of Electronic Publication: 2023 Oct 21 (Print Publication: 2023).
DOI: 10.1016/j.heliyon.2023.e21139
Abstrakt: We studied the effect of Ajuga iva leaves extract (AIE) on the intestinal absorption, motricity and its antioxidant capacity against diarrhea. Wistar rats were divided and received either: castor oil (CO), CO and loperamide or CO and different doses of AIE. AIE prevented dose-dependently CO-induced diarrhea. AIE at 800 mg/kg showed inhibition efficiency on defecation and diarrhea. The pro-oxidant effect of the CO in the small intestine was inhibited significantly in presence of AIE: increasing glutathione peroxidase (GPx) activity and lowering oxygen free radicals (OH°, O 2 °-), carbonyl protein and malondialdehyde (MDA) levels. However, co-administration of AIE in castor oil-exposed groups significantly increased the intestinal contents of calcium and magnesium. AIE exhibits significant anti-diarrheal activity, related in part to its antioxidant properties. Our investigation also provides experimental evidence for the traditional use of this medicinal plant in the treatment of diarrhea.
Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(© 2023 The Authors. Published by Elsevier Ltd.)
Databáze: MEDLINE
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