The impact of brain lesions on tDCS-induced electric fields.

Autor: Evans C; Department for Clinical and Movement Neuroscience, UCL Queen Square Institute of Neurology, University College London, London, UK. carys.evans@ucl.ac.uk., Johnstone A; Department for Clinical and Movement Neuroscience, UCL Queen Square Institute of Neurology, University College London, London, UK., Zich C; Department for Clinical and Movement Neuroscience, UCL Queen Square Institute of Neurology, University College London, London, UK.; Nuffield Department of Clinical Neurosciences, FMRIB, Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, UK., Lee JSA; Department for Clinical and Movement Neuroscience, UCL Queen Square Institute of Neurology, University College London, London, UK., Ward NS; Department for Clinical and Movement Neuroscience, UCL Queen Square Institute of Neurology, University College London, London, UK.; The National Hospital for Neurology and Neurosurgery, London, UK.; UCLP Centre for Neurorehabilitation, London, UK., Bestmann S; Department for Clinical and Movement Neuroscience, UCL Queen Square Institute of Neurology, University College London, London, UK.; Wellcome Centre for Human Neuroimaging, UCL Queen Square Institute of Neurology, University College London, London, UK.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2023 Nov 08; Vol. 13 (1), pp. 19430. Date of Electronic Publication: 2023 Nov 08.
DOI: 10.1038/s41598-023-45905-7
Abstrakt: Transcranial direct current stimulation (tDCS) can enhance motor and language rehabilitation after stroke. Though brain lesions distort tDCS-induced electric field (E-field), systematic accounts remain limited. Using electric field modelling, we investigated the effect of 630 synthetic lesions on E-field magnitude in the region of interest (ROI). Models were conducted for two tDCS montages targeting either primary motor cortex (M1) or Broca's area (BA44). Absolute E-field magnitude in the ROI differed by up to 42% compared to the non-lesioned brain depending on lesion size, lesion-ROI distance, and lesion conductivity value. Lesion location determined the sign of this difference: lesions in-line with the predominant direction of current increased E-field magnitude in the ROI, whereas lesions located in the opposite direction decreased E-field magnitude. We further explored how individualised tDCS can control lesion-induced effects on E-field. Lesions affected the individualised electrode configuration needed to maximise E-field magnitude in the ROI, but this effect was negligible when prioritising the maximisation of radial inward current. Lesions distorting tDCS-induced E-field, is likely to exacerbate inter-individual variability in E-field magnitude. Individualising electrode configuration and stimulator output can minimise lesion-induced variability but requires improved estimates of lesion conductivity. Individualised tDCS is critical to overcome E-field variability in lesioned brains.
(© 2023. The Author(s).)
Databáze: MEDLINE
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