| Autor: |
Kawaguchi N; Department of Veterinary Pathology, Faculty of Agriculture, University of Miyazaki, Miyazaki, Japan., Fuke N; Department of Veterinary Pathology, Faculty of Agriculture, University of Miyazaki, Miyazaki, Japan.; Graduate School of Medicine and Veterinary Medicine, University of Miyazaki, Miyazaki, Japan., Nueangphuet P; Graduate School of Medicine and Veterinary Medicine, University of Miyazaki, Miyazaki, Japan., Pornthummawat A; Graduate School of Medicine and Veterinary Medicine, University of Miyazaki, Miyazaki, Japan.; Department of Pre-Clinic and Applied Animal Science, Faculty of Veterinary Science, Mahidol University, Nakhon Pathom, Thailand., Niazi AM; Graduate School of Medicine and Veterinary Medicine, University of Miyazaki, Miyazaki, Japan., Izzati UZ; Graduate School of Medicine and Veterinary Medicine, University of Miyazaki, Miyazaki, Japan., Hirai T; Department of Veterinary Pathology, Faculty of Agriculture, University of Miyazaki, Miyazaki, Japan.; Graduate School of Medicine and Veterinary Medicine, University of Miyazaki, Miyazaki, Japan., Yamaguchi R; Department of Veterinary Pathology, Faculty of Agriculture, University of Miyazaki, Miyazaki, Japan.; Graduate School of Medicine and Veterinary Medicine, University of Miyazaki, Miyazaki, Japan. |
| Abstrakt: |
After an Egyptian fruit bat (Rousettus aegyptiacus) in a zoo became emaciated and died, a necropsy revealed multiple nodules on the liver and lung surfaces. Microscopy revealed that the liver nodules consisted of neoplastic hepatocytes and showed metastasis in the lung lobes. Most of the neoplastic cells in the liver and lung showed positive labeling for HepPar-1, cytokeratin 19, glypican-3, and Ki-67. Hepatocellular degeneration and necrosis were diffuse in the liver parenchyma. Berlin blue staining revealed large amounts of iron in normal and neoplastic cells. Based on these pieces of evidence, this case was diagnosed as hepatocellular carcinoma with hemochromatosis. This is believed to be the first report of hepatocellular carcinoma in an Egyptian fruit bat that has been immunophenotypically examined in detail by pathological examination. |
