Aporphine and amide alkaloids from Illigera parviflora.

Autor: Xu JJ; Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Guilin Medical University, Guilin 541199, PR China., Yin YP; Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Guilin Medical University, Guilin 541199, PR China., Wei W; Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Guilin Medical University, Guilin 541199, PR China., Tan QG; Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Guilin Medical University, Guilin 541199, PR China; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650302, PR China; Guangxi Key Laboratory of Drug Discovery and Optimization, Guilin Medical University, Guilin 541199, PR China. Electronic address: qgtan@glmc.edu.cn.
Jazyk: angličtina
Zdroj: Fitoterapia [Fitoterapia] 2024 Jan; Vol. 172, pp. 105737. Date of Electronic Publication: 2023 Nov 07.
DOI: 10.1016/j.fitote.2023.105737
Abstrakt: Three undescribed alkaloids (+)-9-hydroxy-N-acetylnordicentrine (1), illigeparvinine (2), and deca-(2E,4Z)-2,4-dienoic acid 4-hydroxy-2-phenethyl amide (3), along with 19 known analogues (4-22), were isolated from the ethnic medicinal plant Illigera parviflora. Their structures were established using NMR, MS, and other spectroscopic analyses as well as X-ray diffraction. Moderate inhibition of human gastric carcinoma (MGC-803) and breast adenocarcinoma (T-47D) cell lines proliferation was observed for actinodaphnine (4) with IC 50 values of 28.74 and 11.65 μM, respectively. These findings contribute new anticancer potential compounds and expand the chemical diversity known from the valuable traditional medicinal plant I. parviflora.
Competing Interests: Declaration of Competing Interest The authors declare that they have no conflicts of interest to this work.
(Copyright © 2023 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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