High doses of hydroxyapatite nanoparticle (nHAP) impairs microcirculation in vivo.

Autor: da Silva de Barros AO; Brazilian Nuclear Energy Commission, Nuclear Engineering Institute, Laboratory of Nanoradiopharmaceuticals and Synthesis of Novel Radiopharmaceuticals, Rio de Janeiro 21941906, Brazil., Ricci-Junior E; Laboratório de Desenvolvimento Galênico, Departamento de Fármacos e Medicamentos, Faculdade de Farmácia, Universidade Federal do Rio de Janeiro (FF/UFRJ), Brazil., Alencar LMR; Federal University of Maranhão, Department of Physics, Laboratory of Biophysics and Nanosystems, Campus Bacanga, Maranhão 65080-805, Brazil., Fechine PBA; Grupo de Química de Materiais Avançados (GQMat), Departamento de Química Analítica e Físico-Química, Universidade Federal do Ceará-UFC, Campus do Pici, CP 12100, Fortaleza, Ceará, CEP 60451-970, Brazil., Andrade Neto DM; Grupo de Química de Materiais Avançados (GQMat), Departamento de Química Analítica e Físico-Química, Universidade Federal do Ceará-UFC, Campus do Pici, CP 12100, Fortaleza, Ceará, CEP 60451-970, Brazil; Federal Institute of Education, Science, and Technology of Ceará, Campus Camocim, 62400-000 Camocim, CE, Brazil., Bouskela E; Universidade do Estado do Rio de Janeiro (UERJ), Laboratório de Pesquisas Clínicas e Experimentais em Biologia Vascular (BioVasc), Rio de Janeiro, 20550-013, Brazil., Santos-Oliveira R; Brazilian Nuclear Energy Commission, Nuclear Engineering Institute, Laboratory of Nanoradiopharmaceuticals and Synthesis of Novel Radiopharmaceuticals, Rio de Janeiro 21941906, Brazil; State University of Rio de Janeiro, Laboratory of Nanoradiopharmaceuticals and Radiopharmacy, Rio de Janeiro, RJ 23070200, Brazil. Electronic address: roliveira@ien.gov.br.
Jazyk: angličtina
Zdroj: Colloids and surfaces. B, Biointerfaces [Colloids Surf B Biointerfaces] 2024 Jan; Vol. 233, pp. 113601. Date of Electronic Publication: 2023 Oct 20.
DOI: 10.1016/j.colsurfb.2023.113601
Abstrakt: Nanoparticles has surrounded the population by their use in electronics, medicine and cosmetics. The exposure to nanoparticles coming from different sources is uncountable as the amount of nanoparticles in which a person is exposed daily. In this direction and considering that microcirculation is the main and most affected system by nanoparticles in the first moment, responsible to transport and deal with nanoparticles internally, we evaluated a massive exposure (1 g/Kg) of a well-known nanoparticle (hydroxyapatite) and the impact on the microvessels. The results showed a massive destruction of venules, arterioles, and capillaries when nHAPs were administered topically. However, systemic administration of high doses of nHAP did not affect microcirculation but altered biochemical parameters of blood samples from treated animals. The data demonstrated that even well documented nanoparticles at high doses might affect the whole-body homeostasis. Finally, the results raise the necessity for further investigation of the effect of nanoparticles in microcirculation and the impact in the whole-body homeostasis.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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