Association of early and current life factors with telomere length in preterm-born children.

Autor: Kotecha EA; Department of Child Health, Cardiff University School of Medicine, Cardiff, United Kingdom., Zhang L; Department of Child Health, Cardiff University School of Medicine, Cardiff, United Kingdom., Aboklaish A; Department of Child Health, Cardiff University School of Medicine, Cardiff, United Kingdom., Cousins M; Department of Child Health, Cardiff University School of Medicine, Cardiff, United Kingdom., Hart K; Department of Child Health, Cardiff University School of Medicine, Cardiff, United Kingdom., Kotecha SJ; Department of Child Health, Cardiff University School of Medicine, Cardiff, United Kingdom., Watkins WJ; Department of Child Health, Cardiff University School of Medicine, Cardiff, United Kingdom., Kotecha S; Department of Child Health, Cardiff University School of Medicine, Cardiff, United Kingdom.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2023 Nov 08; Vol. 18 (11), pp. e0293589. Date of Electronic Publication: 2023 Nov 08 (Print Publication: 2023).
DOI: 10.1371/journal.pone.0293589
Abstrakt: Background: Telomeres shorten after each cell division. Since preterm-born babies are delivered early and often suffer from inflammatory conditions such as bronchopulmonary dysplasia (BPD), their telomere length may be altered.
Objectives: We assessed associations of early and current life factors with telomere length in saliva samples obtained from 7-12-year-old children born at ≤34 weeks' gestation and term-born controls.
Study Design: Relative telomere length was measured by qPCR on extracted DNA. Groups were compared using independent t-tests or ANOVA with post-hoc correction. Linear regression analysis was also used.
Results: 534 children had satisfactory telomere data including 383 who were preterm-born (mean (SD) birthweight 1732g (558g), gestation 31.1 (2.6) weeks) and 151 term-born (3464g (510g); 39.8 (1.3) weeks). Telomere length was longer in children who had intrauterine growth restriction (IUGR) at birth: mean (SD): 464.6 (166.3) vs. 418.6 (110.7) in the no-IUGR group; in females: 440.2 (130.1) vs. 405.7 (101.5) in males; and in the least deprived group (397.8 (95.0) vs. 437.6 (121.9) most vs least deprivation quintile). Differences were most notable in females with IUGR. However, telomere length was not different between the preterm and term groups; the BPD and no BPD groups nor was it related to lung function or cardiovascular measurements. In multivariable regression analyses, telomere length was associated with sex, IUGR and deprivation with the greatest difference observed in females with IUGR.
Conclusions: Telomere length was associated with sex, IUGR and deprivation, especially in females with IUGR, but not with prematurity, BPD, lung function or cardiovascular measurements.
Competing Interests: No competing interests.
(Copyright: © 2023 Kotecha et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
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