| Autor: |
Sharlo KA; Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow, Russia., Vilchinskaya NA; Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow, Russia., Tyganov SA; Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow, Russia., Turtikova OV; Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow, Russia., Lvova ID; Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow, Russia., Sergeeva KV; Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow, Russia., Rukavishnikov IV; Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow, Russia., Shenkman BS; Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow, Russia., Tomilovskaya ES; Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow, Russia., Orlov OI; Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow, Russia. |
| Abstrakt: |
The soleus muscle in humans is responsible for maintaining an upright posture and participating in walking and running. Under muscle disuse, it undergoes molecular signaling changes that result in altered force and work capacity. The triggering mechanisms and pathways of these changes are not yet fully understood. In this article, we aimed to detect the molecular pathways that are involved in the unloading-induced alterations in the human soleus muscle under 6-days of dry immersion. A 6-day dry immersion led to the downregulation of mitochondrial biogenesis and dynamics markers, upregulation of calcium-dependent CaMK II phosphorylation, enhanced PGC1α promoter region methylation, and altered muscle micro-RNA expression, without affecting p-AMPK content or fiber-type transformation. NEW & NOTEWORTHY Dry immersion dysregulates mitochondrial genes expression, affects mi-RNA expression and PGC1 promoter methylation. |
