Crude collection efficiency of CD34 + hematopoietic stem cell apheresis.

Autor: Castillo-Aleman YM; Apheresis Unit, Department of Immunology, Abu Dhabi Stem Cells Center (ADSCC), Abu Dhabi, United Arab Emirates.
Jazyk: angličtina
Zdroj: Journal of clinical apheresis [J Clin Apher] 2024 Feb; Vol. 39 (1), pp. e22096. Date of Electronic Publication: 2023 Nov 08.
DOI: 10.1002/jca.22096
Abstrakt: Understanding the apheresis principles for harvesting hematopoietic stem cells (HSCs) is critical for performing efficient procedures. However, despite significant advances in estimating the collection efficiency (CE) of aphereses, many confounding factors still need to be addressed in the classical calculations. The CE values are unrestricted, and many procedures exhibit CEs of a given cell population greater than 100%. This report introduces a simple equation that estimates the "crude" CE, which ranges from 0% to 100% and intrinsically considers the contribution of donor-related variables such as the pre-procedure mobilization and intra-apheresis recruitment of CD34 + cells (as a convenient marker for HSCs), as well as the performance of the apheresis system itself.
(© 2023 Wiley Periodicals LLC.)
Databáze: MEDLINE
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