Retinal venular vessel diameters are smaller during ten days of bed rest.

Autor: Saloň A; Division of Physiology & Pathophysiology, Otto Loewi Research Center for Vascular Biology, Immunology, and Inflammation, Medical University of Graz, Graz, Austria.; Research Unit 'Gravitational Physiology and Medicine', Physiology, Otto Loewi Research Center, Medical University of Graz, Neue Stiftingtalstraße 6/D.05, 8010, Graz, Austria., Çiftci GM; Division of Physiology & Pathophysiology, Otto Loewi Research Center for Vascular Biology, Immunology, and Inflammation, Medical University of Graz, Graz, Austria.; Department of Psychiatry, University Hospital Münster, Münster, Germany., Zubac D; Institute for Kinesiology Research, Science and Research Centre Koper, Koper, Slovenia.; Department 1 of Internal Medicine, Centre for Integrated Oncology, Aachen, Bonn, Cologne, Düsseldorf, University Hospital of Cologne, Cologne, Germany., Šimunič B; Institute for Kinesiology Research, Science and Research Centre Koper, Koper, Slovenia., Pišot R; Institute for Kinesiology Research, Science and Research Centre Koper, Koper, Slovenia., Narici M; Institute for Kinesiology Research, Science and Research Centre Koper, Koper, Slovenia.; Department of Biomedical Sciences, University of Padua, Padua, Italy., Fredriksen PM; Faculty of Applied Ecology, Agricultural Sciences and Biotechnology, Inland Norway University of Applied Sciences, Lillehammer, Norway., Nkeh-Chungag BN; Department of Biological and Environmental Sciences, Faculty of Health Sciences, Walter Sisulu University PBX1, Mthatha, 5117, South Africa., Sourij H; Internal Medicine, Division of Endocrinology and Diabetology, Interdisciplinary Metabolic Medicine Trials Unit, Medical University of Graz, Graz, Austria., Šerý O; Laboratory of Neurobiology and Molecular Psychiatry, Department of Biochemistry, Faculty of Science, Masaryk University, Kamenice 753/5, 625 00, Brno, Czech Republic.; Laboratory of Neurobiology and Pathological Physiology, Institute of Animal Physiology and Genetics, Czech Academy of Sciences, Veveří 97, 602 00, Brno, Czech Republic., Schmid-Zalaudek K; Division of Physiology & Pathophysiology, Otto Loewi Research Center for Vascular Biology, Immunology, and Inflammation, Medical University of Graz, Graz, Austria.; Research Unit 'Gravitational Physiology and Medicine', Physiology, Otto Loewi Research Center, Medical University of Graz, Neue Stiftingtalstraße 6/D.05, 8010, Graz, Austria., Steuber B; Division of Physiology & Pathophysiology, Otto Loewi Research Center for Vascular Biology, Immunology, and Inflammation, Medical University of Graz, Graz, Austria.; Research Unit 'Gravitational Physiology and Medicine', Physiology, Otto Loewi Research Center, Medical University of Graz, Neue Stiftingtalstraße 6/D.05, 8010, Graz, Austria., De Boever P; Centre for Environmental Sciences, Hasselt University, Hasselt, Belgium., Goswami N; Division of Physiology & Pathophysiology, Otto Loewi Research Center for Vascular Biology, Immunology, and Inflammation, Medical University of Graz, Graz, Austria. nandu.goswami@medunigraz.at.; Research Unit 'Gravitational Physiology and Medicine', Physiology, Otto Loewi Research Center, Medical University of Graz, Neue Stiftingtalstraße 6/D.05, 8010, Graz, Austria. nandu.goswami@medunigraz.at.; Integrative Health, Alma Mater Europaea Maribor, Maribor, Slovenia. nandu.goswami@medunigraz.at.; College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, United Arab Emirates. nandu.goswami@medunigraz.at.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2023 Nov 07; Vol. 13 (1), pp. 19258. Date of Electronic Publication: 2023 Nov 07.
DOI: 10.1038/s41598-023-46177-x
Abstrakt: Older individuals experience cardiovascular dysfunction during extended bedridden hospital or care home stays. Bed rest is also used as a model to simulate accelerated vascular deconditioning occurring during spaceflight. This study investigates changes in retinal microcirculation during a ten-day bed rest protocol. Ten healthy young males (22.9 ± 4.7 years; body mass index: 23.6 ± 2.5 kg·m -2 ) participated in a strictly controlled repeated-measures bed rest study lasting ten days. High-resolution images were obtained using a hand-held fundus camera at baseline, daily during the 10 days of bed rest, and 1 day after re-ambulation. Retinal vessel analysis was performed using a semi-automated software system to obtain metrics for retinal arteriolar and venular diameters, central retinal artery equivalent and central retinal vein equivalent, respectively. Data analysis employed a mixed linear model. At the end of the bed rest period, a significant decrease in retinal venular diameter was observed, indicated by a significantly lower central retinal vein equivalent (from 226.1 µm, CI 8.90, to 211.4 µm, CI 8.28, p = .026), while no significant changes in central retinal artery equivalent were noted. Prolonged bed rest confinement resulted in a significant (up to 6.5%) reduction in retinal venular diameter. These findings suggest that the changes in retinal venular diameter during bedrest may be attributed to plasma volume losses and reflect overall (cardio)-vascular deconditioning.
(© 2023. The Author(s).)
Databáze: MEDLINE
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