Synergism Between Essential Oils and Evaluation of Their Activities with a Focus on Malassezia furfur Control.

Autor:	Cassola F; Faculty of Pharmaceutical Science, State University of Campinas, Campinas, Brazil.; Research Center of Chemical, Biological and Agriculture, Paulínia, Brazil., Ramírez N; Faculty of Pharmaceutical Science, State University of Campinas, Campinas, Brazil.; Research Center of Chemical, Biological and Agriculture, Paulínia, Brazil., Ribeiro G; Institute of Biology, State University of Campinas, Campinas, Brazil., da Silva LHD; Mutagenesis Laboratory, University of Araraquara, Araraquara, Brazil., Gambero A; Life Sciences Center, Pontifical Catholic University of Campinas, Campinas, Brazil., de Oliveira ADSS; Research Center of Chemical, Biological and Agriculture, Paulínia, Brazil., Vieira PMMM; Institute of Biology, State University of Campinas, Campinas, Brazil., Nogueira FAR; Mutagenesis Laboratory, University of Araraquara, Araraquara, Brazil., Duarte MCT; Research Center of Chemical, Biological and Agriculture, Paulínia, Brazil.
Jazyk:	angličtina
Zdroj:	Planta medica [Planta Med] 2024 Feb; Vol. 90 (2), pp. 111-125. Date of Electronic Publication: 2023 Nov 07.
DOI:	10.1055/a-2196-2087
Abstrakt:	Seborrheic dermatitis is a chronic inflammatory disease caused by Malassezia yeast species that affects the regions of the body where the sebaceous glands are present. The combined use of different essential oils (EOs) can increase their spectrum of action. Thus, the present study aimed to evaluate the action of EOs alone and in combination with each other on M. furfur , in planktonic and biofilm form, and their anti-inflammatory and mutagenic potential, in addition to the effects on the viability of cells lines. Of the 40 evaluated EOs, 22 showed activity against M. furfur at 0.5 - 2.0 mg/mL concentrations. Among the most active species, a blend of essential oils (BEOs) composed of Cymbopogon martini (Roxb.) Will. Watson (MIC = 0.5 mg/mL) and Mentha × piperita L. (MIC = 1.0 mg/mL) was selected, which showed a synergistic effect against yeast when evaluated through the checkerboard assay. The fungicidal activity was maintained by the addition of anti-inflammatory oil from Varronia curassavica Jacq. to BEOs. The BEOs also showed activity in the inhibition of biofilm formation and in the eradication of the biofilm formed by M. furfur , being superior to the action of fluconazole. Furthermore, it did not show mutagenic potential and did not interfere with the cell viability of both evaluated cell lines (HaCaT and BMDMs). TNF- α levels were reduced only by C. martini ; however, this property was maintained when evaluating BEOs. BEOs had no effect on IL-8 levels. Thus, the BEOs may be indicated for alternative treatments against seborrheic dermatitis. Competing Interests: The authors declare that they have no conflict of interest. (Thieme. All rights reserved.)
Databáze:	MEDLINE
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