Stent composition and immune response after long-term coronary angioplasty.

Autor:	Sant'Anna VAR; 1Lipids, Atherosclerosis and Vascular Biology Section; Cardiology Division, Department of Medicine, Universidade Federal de São Paulo, São Paulo (São Paulo), Brazil.; 2Department of Immunology, Institute of Biomedical Science IV, University of São Paulo, São Paulo (São Paulo), Brazil.; 3Academic Research Organization, Hospital Albert Einstein, São Paulo (São Paulo), Brazil., Barbosa AHP; 4Hemodynamic and Interventional Cardiology Section; Cardiology Division, Department of Medicine, Universidade Federal de São Paulo, São Paulo (São Paulo), Brazil., Souza RA; 4Hemodynamic and Interventional Cardiology Section; Cardiology Division, Department of Medicine, Universidade Federal de São Paulo, São Paulo (São Paulo), Brazil., Sousa JMA; 4Hemodynamic and Interventional Cardiology Section; Cardiology Division, Department of Medicine, Universidade Federal de São Paulo, São Paulo (São Paulo), Brazil., Monfardini F; 3Academic Research Organization, Hospital Albert Einstein, São Paulo (São Paulo), Brazil., Gidlund M; 2Department of Immunology, Institute of Biomedical Science IV, University of São Paulo, São Paulo (São Paulo), Brazil., Fonseca HAR; 1Lipids, Atherosclerosis and Vascular Biology Section; Cardiology Division, Department of Medicine, Universidade Federal de São Paulo, São Paulo (São Paulo), Brazil.; 2Department of Immunology, Institute of Biomedical Science IV, University of São Paulo, São Paulo (São Paulo), Brazil.; 3Academic Research Organization, Hospital Albert Einstein, São Paulo (São Paulo), Brazil.
Jazyk:	angličtina
Zdroj:	Physiology international [Physiol Int] 2023 Nov 07; Vol. 110 (4), pp. 371-384. Date of Electronic Publication: 2023 Nov 07 (Print Publication: 2023).
DOI:	10.1556/2060.2023.00162
Abstrakt:	Background: There are limited data about the influence of stent composition on immune responses after percutaneous coronary intervention (PCI). Objective: The aim was to compare the effects of PCI with conventional cobalt-chromium bare metal stent (BMS) and drug-eluting stent (DES) implantation on the modulation of humoral and cellular immune responses. Methods: A randomised, single-centre, open pilot study involving patients with stable coronary artery disease eligible for PCI was performed. Blood samples were collected from the peripheral artery (PA) and the coronary sinus (CS) at baseline and 40 weeks following PCI. IgM and IgG autoantibodies (Abs), anti-oxLDL and anti-ApoB-D, as well as cytokine levels were evaluated by enzyme-linked immunosorbent assay. Results: A total of 30 patients of 60 years mean age were included, 68% of whom were men. At the nine-month follow-up, a modulation in the levels of cytokines and autoantibodies was observed in both stent type groups. However, no difference was observed in the modulation of these markers between stents. Conclusion: The stent type promotes modulations in cellular and humoral immune responses in the long-term, with differences in the magnitude of effects in specific immune responses.
Databáze:	MEDLINE
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