[Regulación de la expresión de IL-33 e IL-17 por la modulación farmacológica de HIF-1 en un modelo murino de inflamación alérgica pulmonar].
| Autor: | Baay-Guzmán GJ; Hospital Infantil de México Federico Gómez., Rodríguez-Hernández AP; Hospital Infantil de México Federico Gómez., Anaya-Estrada D; Hospital Infantil de México Federico Gómez., Rodriguez-Jimenez M; Hospital Infantil de México Federico Gómez., Cocoletzi-Bautista JE; Hospital Infantil de México Federico Gómez., Hernández-Cueto D; Hospital Infantil de México Federico Gómez., Luria-Perez R; Hospital Infantil de México Federico Gómez. |
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| Jazyk: | Spanish; Castilian |
| Zdroj: | Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993) [Rev Alerg Mex] 2023 Sep; Vol. 70 (4), pp. 190. |
| DOI: | 10.29262/ram.v70i3.1272 |
| Abstrakt: | Objective: To evaluate the effect of pharmacological modulation of HIF-1 on the expression of IL-33 and IL-17 in a murine model of allergic pulmonary inflam- mation (API) with different degrees of severity. Methods: 5 mice/group received ovalbumin (OVA) 1(mild), 2(moderate) or 3(severe) challenges via i.t. prior to allergen sensitization, in addition to the HIF-1 induction or inhibition groups, received EDHB (OVA+EDHB) i.p. or 2ME (OVA+2ME) i.t. respectively. Control groups received saline solution (SS) in the same way. HE (inflammatory infiltrate), PAS (mucus production) and immunohistochemical staining for HIF-1a, IL-33, IL-17 were performed, quantitatively analyzing by digital pathology. Results: We obtained different degrees of severity with a greater number of challenges, increasing the expression of HIF-1, correlating with the expression of IL-33/IL-17. Increasing or decreasing, respectively by pharmacological modulation. Conclusions: The above suggests that the high expression of HIF-1 favors the production of IL-33 and IL-17 contributing to the damage in lung tissue and the severity of the disease and these can be regulated through the modulation of HIF- 1. (Este obra está bajo una licencia de Creative Commons Reconocimiento-NoComercial 4.0 Internacional.) |
| Databáze: | MEDLINE |
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