[Reproducibilidad clínica de reacciones de hipersensibilidad a fármacos en pruebas de exposición controlada].
| Autor: | Palacios Cañas AA; Hospital General Universitario de Ciudad Real., Meneses Sotomayor JV; Hospital General Universitario de Ciudad Real., Clar Castelló M; Hospital General Universitario de Ciudad Real., Gómez Torrijos E; Hospital General Universitario de Ciudad Real., Borja Segade JM; Hospital General Universitario de Ciudad Real., García Rodríguez R; Hospital General Universitario de Ciudad Real. |
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| Jazyk: | Spanish; Castilian |
| Zdroj: | Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993) [Rev Alerg Mex] 2023 Sep; Vol. 70 (4), pp. 113-120. |
| DOI: | 10.29262/ram.v70i3.1199 |
| Abstrakt: | Objective: To assess the reproducibility of symptoms in drug challenge tests. Methods: The study included patients with positive cutaneous or challenge test throughout 2019. For each patient, clinical suspicion according to Karch-Lasagna algorithm was registered. Primary outcome was the reproducibility of symptoms in the provocation tests using a paired analysis of data with McNemar test. Results: Eighty-nine patients were included, 16 of them presented more than one positive test. Thirty were skin tests positive and 75 reacted to provocation tests. Eighty nine percent of patients who reacted in challenge test were probably or possibly reactors according to Karch-Lasagna scale. Symptoms of initial reaction did not differ from those triggered in challenge tests. Conclusions: Karch-Lasagna scale is useful in predicting the response to drug provocation tests. In most of the positive studies, results were suggested by clinical history and no differences were found between symptoms triggered in challenge test and that referred to in the previous reaction. (Este obra está bajo una licencia de Creative Commons Reconocimiento-NoComercial 4.0 Internacional.) |
| Databáze: | MEDLINE |
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