Practical diagnostic algorithms for Chagas disease: a focus on low resource settings.

Autor:	Gabaldón-Figueira JC; Barcelona Institute for Global Health (ISGlobal), Hospital Clinic-University of Barcelona, Barcelona, Spain., Skjefte M; Population Services International (PSI), Washington, MA, USA., Longhi S; Laboratorio de Biología Molecular de la Enfermedad de Chagas, Instituto de Investigaciones en Ingeniería Genética y Biología Molecular 'Dr Héctor Torres', INGEBI-CONICET, Buenos Aires, Argentina., Escabia E; Barcelona Institute for Global Health (ISGlobal), Hospital Clinic-University of Barcelona, Barcelona, Spain., García LJ; Laboratorio de Biología Molecular de la Enfermedad de Chagas, Instituto de Investigaciones en Ingeniería Genética y Biología Molecular 'Dr Héctor Torres', INGEBI-CONICET, Buenos Aires, Argentina., Ros-Lucas A; Barcelona Institute for Global Health (ISGlobal), Hospital Clinic-University of Barcelona, Barcelona, Spain.; CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III (CIBERINFEC, ISCIII), Madrid, Spain., Martínez-Peinado N; Barcelona Institute for Global Health (ISGlobal), Hospital Clinic-University of Barcelona, Barcelona, Spain., Muñoz-Calderón A; Laboratorio de Biología Molecular de la Enfermedad de Chagas, Instituto de Investigaciones en Ingeniería Genética y Biología Molecular 'Dr Héctor Torres', INGEBI-CONICET, Buenos Aires, Argentina., Gascón J; Barcelona Institute for Global Health (ISGlobal), Hospital Clinic-University of Barcelona, Barcelona, Spain.; CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III (CIBERINFEC, ISCIII), Madrid, Spain., Schijman AG; Laboratorio de Biología Molecular de la Enfermedad de Chagas, Instituto de Investigaciones en Ingeniería Genética y Biología Molecular 'Dr Héctor Torres', INGEBI-CONICET, Buenos Aires, Argentina., Alonso-Padilla J; Barcelona Institute for Global Health (ISGlobal), Hospital Clinic-University of Barcelona, Barcelona, Spain.; CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III (CIBERINFEC, ISCIII), Madrid, Spain.
Jazyk:	angličtina
Zdroj:	Expert review of anti-infective therapy [Expert Rev Anti Infect Ther] 2023 Jul-Dec; Vol. 21 (12), pp. 1287-1299. Date of Electronic Publication: 2023 Nov 24.
DOI:	10.1080/14787210.2023.2279110
Abstrakt:	Introduction: Chagas disease, caused by parasite Trypanosoma cruzi , is the most important neglected tropical disease in the Americas. Two drugs are available for treatment, but access to them is challenging, in part due to complex diagnostic algorithms. These are stage-dependent, involve multiple tests, and are ill-adapted to the reality of vast areas where the disease is endemic. Molecular and serologic tools are used to detect acute and chronic infections, with the performance of the latter showing geographic differences. Breakthroughs in the development of new diagnostic tools include the validation of a loop-mediated isothermal amplification assay for acute infections ( T. cruzi -LAMP), and the regional validation of several rapid diagnostic tests (RDTs) for chronic infection, which simplify testing in resource-limited settings. The literature search was carried out in the MEDLINE database until 1 August 2023. Areas Covered: This review outlines existing algorithms, and proposes new ones focused on point-of-care testing. Expert Opinion: Integrating point-of-care testing into existing diagnostic algorithms in certain endemic areas will increase access to timely diagnosis and treatment. However, additional research is needed to validate the use of these techniques across a wider geography, and to better understand the cost-effectiveness of their large-scale implementation.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu