A Case of Subacute Degeneration of the Spinal Cord Due to Vitamin B12 Deficiency Triggered by Nitrous Oxide Use.
| Autor: | Soh Weng Yan A; Internal Medicine, Countess of Chester Hospital NHS Foundation Trust, Chester, GBR., Ali A; Gastroenterology, Peterborough City Hospital, Peterborough, GBR., Kong J; Internal Medicine, Countess of Chester Hospital NHS Foundation Trust, Chester, GBR., Cooney L; Radiology, Countess of Chester Hospital NHS Foundation Trust, Chester, GBR., Akhtar J; Gastroenterology and Hepatology, Countess of Chester Hospital NHS Foundation Trust, Chester, GBR., Maheswaran T; Gastroenterology and Hepatology, Countess of Chester Hospital NHS Foundation Trust, Chester, GBR., Davies M; Gastroenterology and Hepatology, Countess of Chester Hospital NHS Foundation Trust, Chester, GBR., Prasad Y; Gastroenterology and Hepatology, Countess of Chester Hospital NHS Foundation Trust, Chester, GBR. |
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| Jazyk: | angličtina |
| Zdroj: | Cureus [Cureus] 2023 Nov 05; Vol. 15 (11), pp. e48312. Date of Electronic Publication: 2023 Nov 05 (Print Publication: 2023). |
| DOI: | 10.7759/cureus.48312 |
| Abstrakt: | In this case report, we discuss a young female who presented to the emergency department with a recent onset of weakness, paraesthesia, and gait disturbance suggestive of peripheral neuropathy and gait ataxia. This was attributed to the occasional use of recreational nitrous oxide (N2O) over the past 10 months. Subacute combined degeneration of the spinal cord is a condition affecting the lateral and posterior columns of the spinal cord, mainly caused by demyelination. The use of recreational N2O depletes the levels of vitamin B12 thus leading to this demyelination of the nervous system. Physical examination revealed T6 and T7 and L3 and L4 sensory deficits bilaterally with hyporeflexia in bilateral knee and ankle reflexes with reduced power in the left lower limb as well as a spastic gait. Her vitamin B12 levels were low (98 g/dL). MRI spine showed a high signal in the posterior cord/ dorsal column. The patient made good recovery post-intramuscular B12 administration and physiotherapy with planned outpatient neurology rehabilitation. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2023, Soh Weng Yan et al.) |
| Databáze: | MEDLINE |
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