The diagnostic performance of AFP and PIVKA-II models for non-B non-C hepatocellular carcinoma.

Autor: Tran VT; The Laboratory D Unit, Cancer Center, Cho Ray Hospital, #201B Nguyen Chi Thanh Street, Dist. 5, Ho Chi Minh City, 700000, Vietnam., Phan TT; The Laboratory D Unit, Cancer Center, Cho Ray Hospital, #201B Nguyen Chi Thanh Street, Dist. 5, Ho Chi Minh City, 700000, Vietnam. thanhthangphan@gmail.com., Nguyen TB; The Laboratory D Unit, Cancer Center, Cho Ray Hospital, #201B Nguyen Chi Thanh Street, Dist. 5, Ho Chi Minh City, 700000, Vietnam., Le TT; The Laboratory D Unit, Cancer Center, Cho Ray Hospital, #201B Nguyen Chi Thanh Street, Dist. 5, Ho Chi Minh City, 700000, Vietnam., Tran TT; Department of Clinical Pathology, Cho Ray Hospital, #201B Nguyen Chi Thanh Street, Dist. 5, Ho Chi Minh City, 700000, Vietnam., Nguyen AT; Department of Clinical Pathology, Cho Ray Hospital, #201B Nguyen Chi Thanh Street, Dist. 5, Ho Chi Minh City, 700000, Vietnam., Nguyen HT; Department of Clinical Pathology, Cho Ray Hospital, #201B Nguyen Chi Thanh Street, Dist. 5, Ho Chi Minh City, 700000, Vietnam., Nguyen NB; Department of Clinical Pathology, Cho Ray Hospital, #201B Nguyen Chi Thanh Street, Dist. 5, Ho Chi Minh City, 700000, Vietnam., Ho TT; The Laboratory D Unit, Cancer Center, Cho Ray Hospital, #201B Nguyen Chi Thanh Street, Dist. 5, Ho Chi Minh City, 700000, Vietnam., Pho SP; The Laboratory D Unit, Cancer Center, Cho Ray Hospital, #201B Nguyen Chi Thanh Street, Dist. 5, Ho Chi Minh City, 700000, Vietnam., Nguyen TT; The Laboratory D Unit, Cancer Center, Cho Ray Hospital, #201B Nguyen Chi Thanh Street, Dist. 5, Ho Chi Minh City, 700000, Vietnam., Nguyen HT; The Laboratory D Unit, Cancer Center, Cho Ray Hospital, #201B Nguyen Chi Thanh Street, Dist. 5, Ho Chi Minh City, 700000, Vietnam., Mai HT; The Laboratory D Unit, Cancer Center, Cho Ray Hospital, #201B Nguyen Chi Thanh Street, Dist. 5, Ho Chi Minh City, 700000, Vietnam., Pham BT; The Laboratory D Unit, Cancer Center, Cho Ray Hospital, #201B Nguyen Chi Thanh Street, Dist. 5, Ho Chi Minh City, 700000, Vietnam., Nguyen KD; Scientific Research Department, Cho Ray Hospital, #201B Nguyen Chi Thanh Street, Dist. 5, Ho Chi Minh City, 700000, Vietnam., Le BT; Department of General Director, Cho Ray Hospital, #201B Nguyen Chi Thanh Street, Dist. 5, Ho Chi Minh City, 700000, Vietnam., Nguyen TT; Department of General Director, Cho Ray Hospital, #201B Nguyen Chi Thanh Street, Dist. 5, Ho Chi Minh City, 700000, Vietnam., Nguyen ST; Department of General Director, Cho Ray Hospital, #201B Nguyen Chi Thanh Street, Dist. 5, Ho Chi Minh City, 700000, Vietnam.
Jazyk: angličtina
Zdroj: BMC research notes [BMC Res Notes] 2023 Nov 06; Vol. 16 (1), pp. 317. Date of Electronic Publication: 2023 Nov 06.
DOI: 10.1186/s13104-023-06600-y
Abstrakt: Objective: This study aims to describe the diagnostic performance of alpha-fetoprotein (AFP), alpha-fetoprotein L3 isoform (AFP-L3), protein induced by vitamin K absence II (PIVKA-II), and combined biomarkers for non-B non-C hepatocellular carcinoma (NBNC-HCC).
Results: A total of 681 newly-diagnosed primary liver disease subjects (385 non-HCC, 296 HCC) who tested negativity for the hepatitis B surface antigen (HBsAg) and hepatitis C antibody (anti-HCV) enrolled in this study. At the cut-off point of 3.8 ng/mL, AFP helps to discriminate HCC from non-HCC with an area under the curve (AUC) value of 0.817 (95% confidence interval [CI]: 0.785-0.849). These values of AFP-L3 (cut-off 0.9%) and PIVKA-II (cut-off 57.7 mAU/mL) were 0.758 (95%CI: 0.725-0.791) and 0.866 (95%CI: 0.836-0.896), respectively. The Bayesian Model Averaging (BMA) statistic identified the optimal model, including patients' age, aspartate aminotransferase, AFP, and PIVKA-II combination, which helps to classify HCC with better performance (AUC = 0.896, 95%CI: 0.872-0.920, P < 0.001). The sensitivity and specificity of the optimal model reached 81.1% (95%CI: 76.1-85.4) and 83.2% (95%CI: 78.9-86.9), respectively. Further analyses indicated that AFP and PIVKA-II markers and combined models have good-to-excellent performance detecting curative resected HCC, separating HCC from chronic hepatitis, dysplastic, and hyperplasia nodules.
(© 2023. The Author(s).)
Databáze: MEDLINE
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