Voluntary alcohol intake alters the motivation to seek intravenous oxycodone and neuronal activation during the reinstatement of oxycodone and sucrose seeking.

Autor: Wilkinson CS; Psychology Department, University of Florida, 114 Psychology, 945 Center Dr., Gainesville, FL, 32611, USA.; Center for Addiction Research and Education, University of Florida, Gainesville, FL, USA., Blount HL; Psychology Department, University of Florida, 114 Psychology, 945 Center Dr., Gainesville, FL, 32611, USA.; Center for Addiction Research and Education, University of Florida, Gainesville, FL, USA., Davis S; Psychology Department, University of Florida, 114 Psychology, 945 Center Dr., Gainesville, FL, 32611, USA.; Center for Addiction Research and Education, University of Florida, Gainesville, FL, USA., Rojas G; Psychology Department, University of Florida, 114 Psychology, 945 Center Dr., Gainesville, FL, 32611, USA., Wu L; Psychology Department, University of Florida, 114 Psychology, 945 Center Dr., Gainesville, FL, 32611, USA., Murphy NP; Orthodontics Department, University of Florida, Gainesville, FL, USA., Schwendt M; Psychology Department, University of Florida, 114 Psychology, 945 Center Dr., Gainesville, FL, 32611, USA.; Center for Addiction Research and Education, University of Florida, Gainesville, FL, USA., Knackstedt LA; Psychology Department, University of Florida, 114 Psychology, 945 Center Dr., Gainesville, FL, 32611, USA. knack@ufl.edu.; Center for Addiction Research and Education, University of Florida, Gainesville, FL, USA. knack@ufl.edu.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2023 Nov 06; Vol. 13 (1), pp. 19174. Date of Electronic Publication: 2023 Nov 06.
DOI: 10.1038/s41598-023-46111-1
Abstrakt: Opioid-alcohol polysubstance use is prevalent and worsens treatment outcomes. Here we assessed whether co-consumption of oxycodone and alcohol influence the intake of one another, demand for oxycodone, and the neurocircuitry underlying cue-primed reinstatement of oxycodone-seeking. Male and female rats underwent oxycodone intravenous self-administration (IVSA) with homecage access to alcohol (20% v/v) and/or water immediately after the IVSA session. Next, economic demand for intravenous oxycodone was assessed while access to alcohol and/or water continued. Control rats self-administered sucrose followed by access to alcohol and/or water. Rats underwent a cue-primed reinstatement test and brains were processed for c-fos mRNA expression. While both sexes decreased oxycodone intake if they had access to alcohol, and decreased alcohol intake if they had access to oxycodone, only female oxycodone + alcohol rats exhibited decreased demand elasticity and increased cue-primed reinstatement. Alcohol consumption increased the number of basolateral and central amygdala neurons activated during sucrose and oxycodone reinstatement and the number of ventral and dorsal striatum neurons engaged by sucrose reinstatement. Nucleus accumbens shell dopamine 1 receptor expressing neurons displayed activation patterns consistent with oxycodone reinstatement. Thus, alcohol alters the motivation to seek oxycodone in a sex-dependent manner and the neural circuitry engaged by cue-primed reinstatement of sucrose and oxycodone-seeking.
(© 2023. The Author(s).)
Databáze: MEDLINE
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