| Autor: |
Bhushan A; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India.; Natural Products and Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Jammu, India., Rani D; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India.; Natural Products and Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Jammu, India., Lone BA; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India.; Natural Products and Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Jammu, India., Tabassum M; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India.; Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Jammu, India., Gupta AP; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India.; Quality Management and Instrumentation Division, CSIR-Indian Institute of Integrative Medicine, Jammu, India., Mondhe DM; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India.; Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Jammu, India., Gairola S; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India.; Plant Sciences and Agrotechnology Division, CSIR-Indian Institute of Integrative Medicine, Jammu, India.; Department of Botany and Microbiology, HNB Garwal University, Srinagar, India., Gupta PN; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India.; Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Jammu, India., Gupta P; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India.; Natural Products and Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Jammu, India. |
| Abstrakt: |
Three new eudesmane type rare sesquiterpene lactone galactosides, costunosides A-C ( 1-3) were isolated from the rhizomes of Aucklandia costus along with ten known compounds ( 4-13 ). Costunosides A-C ( 1-3) are the first example of naturally eudesmane glycosides containing a β -galactopyranoside moiety. The structure and relative configurations of these compounds were established by comprehensive analysis of MS and, in particular 1D/2D NMR spectroscopic data. The isolated compounds were tested against a panel of human cancer cell lines, where compounds 3, 6 and 7 have shown promising cytotoxic activity against PC-3, HCT-116 and A549 cell lines with IC 50 values in the range of 3.4 µM to 9.3 µM, respectively. Costunosides A-C ( 1-3) were also screened for inhibition assay of acetyl-cholinesterase (AChE), and butyrylcholinesterase (BChE) and found inactive at a concentration of 10 µM. |
