Differentiating Between V- and G-Series Nerve Agent and Simulant Vapours Using Fluorescent Film Responses.

Autor: Fan S; Centre for Organic Photonics & Electronics (COPE), School of Chemistry & Molecular Biosciences, University of Queensland, St. Lucia, QLD, 4072, Australia., Loch AS; Centre for Organic Photonics & Electronics (COPE), School of Chemistry & Molecular Biosciences, University of Queensland, St. Lucia, QLD, 4072, Australia., Vongsanga K; CBRN Defence Branch, Sensors and Effectors Division, Defence Science and Technology Group, Fishermans Bend, VIC, 3207, Australia., Dennison GH; CBRN Defence Branch, Sensors and Effectors Division, Defence Science and Technology Group, Fishermans Bend, VIC, 3207, Australia.; Electro Optic Sensing and Electromagnetic Warfare, Sensors and Effectors Division, Defence Science and Technology Group, Edinburgh, SA, 5111, Australia., Burn PL; Centre for Organic Photonics & Electronics (COPE), School of Chemistry & Molecular Biosciences, University of Queensland, St. Lucia, QLD, 4072, Australia., Gentle IR; Centre for Organic Photonics & Electronics (COPE), School of Chemistry & Molecular Biosciences, University of Queensland, St. Lucia, QLD, 4072, Australia., Shaw PE; Centre for Organic Photonics & Electronics (COPE), School of Chemistry & Molecular Biosciences, University of Queensland, St. Lucia, QLD, 4072, Australia.
Jazyk: angličtina
Zdroj: Small methods [Small Methods] 2024 Jan; Vol. 8 (1), pp. e2301048. Date of Electronic Publication: 2023 Nov 06.
DOI: 10.1002/smtd.202301048
Abstrakt: In-field rapid and reliable identification of nerve agents is critical for the protection of Defence and National Security personnel as well as communities. Fluorescence-based detectors can be portable and provide rapid detection of chemical threats. However, most current approaches cannot differentiate between dilute vapors of nerve agent classes and are susceptible to false positives due to the presence of common acids. Here a fluorescence-based method is shown for rapid differentiation between the V-series and phosphonofluoridate G-series nerve agents and avoids false positives due to common acids. Differentiation is achieved through harnessing two different mechanisms. Detection of the V-series is achieved using photoinduced hole transfer whereby the fluorescence of the sensing material is quenched in the presence of the V-series agent. The G-series is detected using a turn-on mechanism in which a silylated excited state intramolecular proton transfer sensing molecule is selectively deprotected by hydrogen fluoride, which is typically found as a contaminant and/or breakdown product in G-series agents such as sarin. The strategy provided discrimination between classes, as the sensor for the G-series agent class is insensitive to the V-series agent, and vice versa, and neither responded to common acids.
(© 2023 The Authors. Small Methods published by Wiley-VCH GmbH.)
Databáze: MEDLINE
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