Acute cerebellitis following COVID-19 infection associated with autoantibodies to glutamate receptors: a case report.

Autor: Watanabe T; Division of Neurology, Department of Internal Medicine, Showa University Northern Yokohama Hospital, 35-1 Chigasaki-chuo Tsuzuki-ku, Yokohama, Kanagawa, 224-8503, Japan., Kakinuma Y; Division of Neurology, Department of Internal Medicine, Showa University Northern Yokohama Hospital, 35-1 Chigasaki-chuo Tsuzuki-ku, Yokohama, Kanagawa, 224-8503, Japan., Watanabe K; Division of Neurology, Department of Internal Medicine, Showa University Northern Yokohama Hospital, 35-1 Chigasaki-chuo Tsuzuki-ku, Yokohama, Kanagawa, 224-8503, Japan., Kinno R; Division of Neurology, Department of Internal Medicine, Showa University Northern Yokohama Hospital, 35-1 Chigasaki-chuo Tsuzuki-ku, Yokohama, Kanagawa, 224-8503, Japan. kinno@med.showa-u.ac.jp.
Jazyk: angličtina
Zdroj: Journal of neurovirology [J Neurovirol] 2023 Dec; Vol. 29 (6), pp. 731-733. Date of Electronic Publication: 2023 Nov 06.
DOI: 10.1007/s13365-023-01183-7
Abstrakt: While COVID-19 infection by the SARS-CoV-2 virus was initially identified as a respiratory disease, mounting evidence suggests its association with various neurological issues as well. Notably, COVID-19 has been linked to acute cerebellitis (AC) and post-infectious cerebellar ataxia. The precise underlying mechanisms behind these neurological effects remain unclear. Our case report describes AC following COVID-19 infection, associated with autoantibodies to glutamate receptors (GluRs), hinting at immunological involvement. The case is a 56-year-old woman who experienced fever and fatigue due to COVID-19 infection. About 2 weeks after these symptoms improved, she showed cerebellar symptoms such as ocular overshoot and ataxia when presenting to our hospital. Her cerebrospinal fluid (CSF) findings were normal. Brain MRI revealed cerebellar abnormalities. Treatment with methylprednisolone led to symptom improvement. Later tests of CSF yielded positive results for autoantibodies to GluRs. Our findings suggest a possible immune-mediated mechanism in the onset of AC following COVID-19 infection. Clinicians should consider the possibility of immunological pathogenesis when diagnosing cerebellar symptoms after COVID-19 infection.
(© 2023. The Author(s).)
Databáze: MEDLINE
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