Epidemiology, clinical presentation and treatment outcomes in patients with COVID-19 in an ambulatory setting: a cross sectional study during the massive SARS-CoV-2 wave in India.

Autor:	Sharma S; Department of Pharmacology, All India Institute of Medical Sciences, Mangalagiri, India., Upparakadiyala R; Department of General Medicine, All India Institute of Medical Sciences, Mangalagiri, 522503, India., Chenchula S; Department of Pharmacology, All India Institute of Medical Sciences, Mangalagiri, India., Chavan M; Department of Pharmacology, All India Institute of Medical Sciences, Mangalagiri, India., Rangari G; Department of Pharmacology, All India Institute of Medical Sciences, Mangalagiri, India., Misra AK; Department of Pharmacology, All India Institute of Medical Sciences, Mangalagiri, India.
Jazyk:	angličtina
Zdroj:	Bioinformation [Bioinformation] 2023 Sep 30; Vol. 19 (9), pp. 939-945. Date of Electronic Publication: 2023 Sep 30 (Print Publication: 2023).
DOI:	10.6026/97320630019939
Abstrakt:	The COVID-19 pandemic, caused by SARS-CoV-2, has profoundly affected developing countries like India. This retrospective cross-sectional analysis investigated epidemiological, clinical characteristics, treatment strategies, and outcomes for hospitalized COVID-19 patients during the Massive SARS-CoV-2 Wave in India. Among 233 patients, the median age was 47.33 years, mostly male. Hospital stays averaged 8.4 days. Common symptoms include fever (88.41%), dry cough (56.2%), myalgia (44.20%), and shortness of breath (22.8%). The most common comorbidities were diabetes mellitus (52%) and hypertension (47.2%). Elevated biomarkers include D-dimer (24.4%), CRP (32.1%), ferritin (26.60%), and others. Prescription analysis revealed that antibiotics (42.6%), Antivirals (37%), anthelmintics (20.30%), vitamins and nutritional supplements (20.71%) and glucocorticoids (12.8%) were the most commonly prescribed. Oxygen therapy was needed by 19.31% of patients in the moderate and severe categories within 24 hours of admission. The mortality rate was 8.58%. The surge led to increased hospitalizations and mortality, particularly among young adults. Diabetes and hypertension were correlated with mortality. Irregular use of drugs lacking evidence, like antibiotics and anthelmintics, vitamins and nutritional supplements, was observed in COVID-19 management. This study underscores the impact of the pandemic in India and highlights the need for evidence-based treatments. Competing Interests: None to declare. (© 2023 Biomedical Informatics.)
Databáze:	MEDLINE
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