Efficacy and Safety Profile of Ticagrelor Versus Clopidogrel in Percutaneous Coronary Intervention (PCI) for Acute Coronary Syndrome (ACS): A Systematic Review and Meta-Analysis.

Autor:	Maqbool S; Department of Cardiology, Rawalpindi Medical University, Rawalpindi, PAK., Ali MS; Department of Cardiology, Rawalpindi Medical University, Rawalpindi, PAK., Rehman A; Department of Cardiology, Rawalpindi Medical University, Rawalpindi, PAK., Ur Rehman ME; Department of Cardiology, Rawalpindi Medical University, Rawalpindi, PAK., Iqbal J; Department of Neurosurgery, Mayo Hospital, Lahore, PAK., Razzaq A; Department of Cardiology, Rawalpindi Medical University, Rawalpindi, PAK., Kamal A; Department of Medicine, The University of Jordan, Amman, JOR., Shivamadhu SS; Department of Medicine, Ramaiah Medical College, Bengaluru, IND., Afzal M; Department of Medicine, Fatima Jinnah Medical University, Lahore, PAK., Fazal F; Department of Cardiology, Rawalpindi Medical University, Rawalpindi, PAK., Basit J; Department of Cardiology, Rawalpindi Medical University, Rawalpindi, PAK., Khalid SA; Department of Forensic, Federal Medical College, Islamabad, PAK.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2023 Oct 04; Vol. 15 (10), pp. e46455. Date of Electronic Publication: 2023 Oct 04 (Print Publication: 2023).
DOI:	10.7759/cureus.46455
Abstrakt:	The utilization of individualized anti-platelet therapy is of paramount significance in this era of cardiovascular advancement. This meta-analysis is also aiming to get more information relating to the effectiveness of ticagrelor versus clopidogrel among patients undergoing percutaneous coronary intervention (PCI) for acute coronary syndrome (ACS). A comprehensive literature search was done through various databases like PubMed, Google Scholar, EMBASE, Web of Science, and the Cochrane Database Library from January 15, 2023, to February 23, 2023. After careful screening, eight articles with highly significant variables were involved in the synthesis of this meta-analysis. Data analysis was done through Review Manager (RevMan, Version 5.4; The Cochrane Collaboration, Copenhagen, Denmark). In our study, ticagrelor and clopidogrel were evaluated in 10614 and 14662 patients, respectively. Ticagrelor was significantly superior to Clopidogrel in terms of all-cause mortality (RR 0.79, 95% CI 0.69-0.91, p = 0.001), risk of MI (RR 0.74, 95% CI 0.61-0.89, p = 0.001), and stroke (RR 0.64, 95% CI 0.42-0.98, p = 0.04), but a higher risk of bleeding events was observed with Ticagrelor (RR 1.36, 95% CI 1.04-1.79, p = 0.03). The two regimens were comparable in terms of stent thrombosis. Ticagrelor was found to be best in terms of reducing post-PCI myocardial infarction, stroke, stent thrombosis, and all other mortality events in comparison to Clopidogrel. However, the bleeding events were of significant concern for the utilization of ticagrelor and required further investigations. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2023, Maqbool et al.)
Databáze:	MEDLINE
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