Histopathological features in the clinical specimens with tuberculosis diagnosis by BACTEC MGIT 960 culture.

Autor:	Cuong NK; Department of Respiratory Tuberculosis, National Lung Hospital, Hanoi, Vietnam.; Department of Tuberculosis and Lung Diseases, Hanoi Medical University, Hanoi, Vietnam., Thanh DV; Department of Infectious Diseases, Hanoi Medical University, Hanoi, Vietnam., Luong DV; Centre of Lung Transplantation, National Lung Hospital, Hanoi, Vietnam., Manh The N; Department of Respiratory Tuberculosis, National Lung Hospital, Hanoi, Vietnam., Duc Thai T; Department of Respiratory Tuberculosis, National Lung Hospital, Hanoi, Vietnam., Tran Thi Tuan A; Department of Pathology, National Lung Hospital, Hanoi, Vietnam., Thu Ha D; Department of Microbiology and National Tuberculosis Reference Laboratory, National Lung Hospital, Hanoi, Vietnam., Dat VQ; Department of Infectious Diseases, Hanoi Medical University, Hanoi, Vietnam.; Hanoi Medical University Hospital, Hanoi Medical University, Hanoi, Vietnam.
Jazyk:	angličtina
Zdroj:	Journal of clinical tuberculosis and other mycobacterial diseases [J Clin Tuberc Other Mycobact Dis] 2023 Sep 29; Vol. 33, pp. 100401. Date of Electronic Publication: 2023 Sep 29 (Print Publication: 2023).
DOI:	10.1016/j.jctube.2023.100401
Abstrakt:	Diagnosis of extrapulmonary tuberculosis remains challenging in lower-middle income countries with high burden of tuberculosis (TB). This study aims to describe the histological characteristics in biopsy samples from patients with confirmed TB. This is a retrospective study of clinical biopsy specimens with positive liquid medium culture for Mycobacterium tuberculosis and histopathological examination in the National Lung Hospital in Vietnam. Among 1045 biopsy specimens with mycobacteria culture, the overall rate of growth of Mycobacteria tuberculosis in culture was 20.7% (216/1045). The positivity rates of MIGT culture among surgical biopsy specimens were 75% in bone specimen, followed by vertebral specimens (51.3%), and joint specimens (26.4%). For specimens obtained by the fine needle aspiration, the positivity rates of MIGT culture were 26.3% in lymph node and 25.3% in pleural specimen. Among specimens with culture confirmation of TB, the most common histopathoglogical suggestive finding of TB was the presence of epithelioid cell (83.3%), Langhans giant cells (75.9%), and caseous necrosis (75.5%). The high proportion of histological features suggestive of TB among the TB culture confirmed biopsy samples support for further evaluation of histological examination and its combination with other recommended rapid molecular assays in specimens with suspicion of TB. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2023 The Authors.)
Databáze:	MEDLINE
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