Atypical presentations of primary acquired hypothyroidism - a case series.

Autor: Pravin RR; General Paediatrics, KK Women's & Children's Hospital, Singapore, Singapore. rr.pravin@mohh.com.sg.; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. rr.pravin@mohh.com.sg., Kan SY; General Paediatrics, KK Women's & Children's Hospital, Singapore, Singapore., Soh SY; General Paediatrics, KK Women's & Children's Hospital, Singapore, Singapore.; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Chan D; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Endocrinology Service, KK Women's & Children's Hospital, Singapore, Singapore.; Duke-NUS Medical School, National University of Singapore, Singapore, Singapore.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore., Farhad Vasanwala R; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Endocrinology Service, KK Women's & Children's Hospital, Singapore, Singapore.; Duke-NUS Medical School, National University of Singapore, Singapore, Singapore.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
Jazyk: angličtina
Zdroj: BMC endocrine disorders [BMC Endocr Disord] 2023 Nov 06; Vol. 23 (1), pp. 242. Date of Electronic Publication: 2023 Nov 06.
DOI: 10.1186/s12902-023-01488-y
Abstrakt: Primary acquired hypothyroidism in children manifests with a myriad of clinical presentations. Clinical features can be insidious in nature, often under the guise of non-specific presentations to other subspecialties prior to referral to the endocrinologist. Growth failure is a hallmark feature in these children alongside their presenting clinical symptomology which needs to be identified through detailed history, physical examination and analysis of the growth charts. In this case series, we discuss 5 atypical presentations of acquired primary hypothyroidism with multisystemic involvement, including musculoskeletal, hepatobiliary, gynaecological and haematological manifestations. This is of importance as untreated hypothyroidism leads to fatigue, decreased physical activity, suboptimal height gain, disordered puberty and poor neurocognitive development in children with long term detrimental outcomes.
(© 2023. The Author(s).)
Databáze: MEDLINE
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