The influence of environmental factors on premature ovarian insufficiency and ovarian aging.

Autor: Evangelinakis N; 3rd Department of Obstetrics and Gynecology, Aristotle University of Thessaloniki 54124, Thessaloniki, Greece., Geladari EV; 3rd Internal Medicine Department, Evangelismos General Hospital, Liver Outpatient Clinic, Ypsilantou 45-47, Athens 106 76, Greece., Geladari CV; Hellenic Society of Environmental and Climate Medicine, 92 Danaon Street, 13122 Ilion, Athens, Greece., Kontogeorgi A; Department of Obstetrics and Gynecology, University of Crete, Andrea Kalokerinou 13, Giofirakia, 71500 Heraklion, Crete, Greece., Papaioannou GK; 3rd Department of Obstetrics and Gynecology, Aristotle University of Thessaloniki 54124, Thessaloniki, Greece., Peppa M; 2nd Department of Internal Medicine, Research Institute and Diabetes Center, National and Kapodistrian University of Athens, Attikon University Hospital 1 Rimini Street, 12462, Chaidari, Greece., Kalantaridou S; 3rd Department of Obstetrics and Gynecology, National and Kapodistrian University of Athens, Attikon University Hospital 1 Rimini Street, 12462 Chaidari, Athens, Greece. Electronic address: sophiakalantaridou@gmail.com.
Jazyk: angličtina
Zdroj: Maturitas [Maturitas] 2024 Jan; Vol. 179, pp. 107871. Date of Electronic Publication: 2023 Nov 03.
DOI: 10.1016/j.maturitas.2023.107871
Abstrakt: Premature ovarian insufficiency and ovarian aging are complex conditions that affect women's reproductive health and overall well-being. They are both characterized by hypergonadotropic hypogonadism and infertility, and together affect about 1 in 100 women by the age of 40. This review explores the influence of environmental factors on the development and progression of premature ovarian insufficiency and ovarian aging. When referring to environmental factors, we include a wide range of external agents and conditions, including chemicals, socioeconomic factors and lifestyle choices. Through a review of the literature, we attempt to highlight the link between environmental factors and ovarian health. We examine the impact of endocrine-disrupting chemicals, such as bisphenol A and phthalates, on ovarian function and investigate the mechanisms by which these chemicals can disrupt hormone signaling pathways, leading to alterations in ovarian reserve, oocyte quality, and folliculogenesis. Moreover, we explore lifestyle factors like obesity, stress, smoking and alcohol in relation to their effects on ovarian aging. Epigenetic changes may play a crucial role in the prevalence of premature ovarian insufficiency. Understanding the impact of environmental factors on premature ovarian insufficiency and ovarian aging is very important in public and clinical health contexts. By identifying risk factors, healthcare providers can develop targeted and strategic prevention and intervention plans. Furthermore, this knowledge can promote reproductive health and minimize exposure to harmful environmental agents.
Competing Interests: Declaration of competing interest The authors declare that they have no competing interest.
(Copyright © 2023 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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