Soft and Flexible Bioelectronic Micro-Systems for Electronically Controlled Drug Delivery.

Autor: Mariello M; Department of Engineering Science, Institute of Biomedical Engineering (IBME), University of Oxford, Oxford, OX3 7DQ, UK., Eş I; Department of Engineering Science, Institute of Biomedical Engineering (IBME), University of Oxford, Oxford, OX3 7DQ, UK., Proctor CM; Department of Engineering Science, Institute of Biomedical Engineering (IBME), University of Oxford, Oxford, OX3 7DQ, UK.
Jazyk: angličtina
Zdroj: Advanced healthcare materials [Adv Healthc Mater] 2024 Sep; Vol. 13 (24), pp. e2302969. Date of Electronic Publication: 2023 Nov 27.
DOI: 10.1002/adhm.202302969
Abstrakt: The concept of targeted and controlled drug delivery, which directs treatment to precise anatomical sites, offers benefits such as fewer side effects, reduced toxicity, optimized dosages, and quicker responses. However, challenges remain to engineer dependable systems and materials that can modulate host tissue interactions and overcome biological barriers. To stay aligned with advancements in healthcare and precision medicine, novel approaches and materials are imperative to improve effectiveness, biocompatibility, and tissue compliance. Electronically controlled drug delivery (ECDD) has recently emerged as a promising approach to calibrated drug delivery with spatial and temporal precision. This article covers recent breakthroughs in soft, flexible, and adaptable bioelectronic micro-systems designed for ECDD. It overviews the most widely reported operational modes, materials engineering strategies, electronic interfaces, and characterization techniques associated with ECDD systems. Further, it delves into the pivotal applications of ECDD in wearable, ingestible, and implantable medical devices. Finally, the discourse extends to future prospects and challenges for ECDD.
(© 2023 The Authors. Advanced Healthcare Materials published by Wiley‐VCH GmbH.)
Databáze: MEDLINE
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