Closed-loop cervical epidural stimulation partially restores ipsilesional diaphragm EMG after acute C 2 hemisection.

Autor: Mickle AR; Department of Neuroscience, University of Florida, 1149 Newell Dr, Gainesville, FL 32610, United States; Breathing Research and Therapeutics Center, University of Florida, 1149 Newell Dr, Gainesville, FL 32610, United States; McKnight Brain Institute, University of Florida, 1149 Newell Dr, Gainesville, FL 32610, United States. Electronic address: alyssa.mickle@ufl.edu., Peñaloza-Aponte JD; Department of Neuroscience, University of Florida, 1149 Newell Dr, Gainesville, FL 32610, United States; Breathing Research and Therapeutics Center, University of Florida, 1149 Newell Dr, Gainesville, FL 32610, United States; McKnight Brain Institute, University of Florida, 1149 Newell Dr, Gainesville, FL 32610, United States., Coffey R; Department of Physiology and Aging, University of Florida, 1600 SW Archer Rd M552, Gainesville, FL 32603, United States., Hall NA; Department of Physiology and Aging, University of Florida, 1600 SW Archer Rd M552, Gainesville, FL 32603, United States., Baekey D; Department of Neuroscience, University of Florida, 1149 Newell Dr, Gainesville, FL 32610, United States; Breathing Research and Therapeutics Center, University of Florida, 1149 Newell Dr, Gainesville, FL 32610, United States; McKnight Brain Institute, University of Florida, 1149 Newell Dr, Gainesville, FL 32610, United States., Dale EA; Department of Neuroscience, University of Florida, 1149 Newell Dr, Gainesville, FL 32610, United States; Breathing Research and Therapeutics Center, University of Florida, 1149 Newell Dr, Gainesville, FL 32610, United States; McKnight Brain Institute, University of Florida, 1149 Newell Dr, Gainesville, FL 32610, United States; Department of Physiology and Aging, University of Florida, 1600 SW Archer Rd M552, Gainesville, FL 32603, United States.
Jazyk: angličtina
Zdroj: Respiratory physiology & neurobiology [Respir Physiol Neurobiol] 2024 Feb; Vol. 320, pp. 104182. Date of Electronic Publication: 2023 Nov 01.
DOI: 10.1016/j.resp.2023.104182
Abstrakt: Cervical spinal cord injury creates lasting respiratory deficits which can require mechanical ventilation long-term. We have shown that closed-loop epidural stimulation (CL-ES) elicits respiratory plasticity in the form of increased phrenic network excitability (Malone et. al., E Neuro, Vol 9, 0426-21.2021, 2022); however, the ability of this treatment to create functional benefits for breathing function per se after injury has not been demonstrated. Here, we demonstrate in C2 hemisected anesthetized rats, a 20-minute bout of CL-ES administered at current amplitudes below the motor threshold restores paralyzed hemidiaphragm activity in-phase with breathing while potentiating contralesional activity. While this acute bout of stimulation did not elicit the increased network excitability seen in our chronic model, a subset of stimulated animals continued spontaneous ipsilesional diaphragm activity for several seconds after stopping stimulation. These results support the use of CL-ES as a therapeutic to rescue breathing after high cervical spinal cord injury, with the potential to lead to lasting recovery and device independence.
Competing Interests: Declaration of Competing Interest None.
(Copyright © 2023 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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