In Vitro Protection and Titer Duration of Anthrax-Specific Antibodies Following Subcutaneous Vaccination of White-tailed Deer (Odocoileus virginianus) with Bacillus anthracis Sterne 34F2 Strain Spores.

Autor:	Nunez CM; Cook Wildlife Lab, Department of Veterinary Pathobiology, Texas A&M University, College of Veterinary Medicine and Biomedical Sciences, College Station, Texas 77843, USA.; These authors contributed equally to the work., Benn JS; Cook Wildlife Lab, Department of Veterinary Pathobiology, Texas A&M University, College of Veterinary Medicine and Biomedical Sciences, College Station, Texas 77843, USA.; Current address: Caesar Kleberg Wildlife Research Institute, Texas A&M University-Kingsville, 700 University Blvd., MSC 218, Kingsville, Texas 78363, USA.; These authors contributed equally to the work., Blue-McLendon A; Winnie Carter Wildlife Center, Department of Veterinary Pharmacology and Physiology, Texas A&M University, College Station, Texas 77843, USA., Chaki SP; Global Health Research Complex, Division of Research, Texas A&M University, College Station, Texas 77843, USA., Ficht TA; Ficht Encapsulation Lab, Department of Veterinary Pathobiology, Texas A&M University, College Station, Texas 77843, USA., Rice-Ficht AC; Ficht Encapsulation Lab, Department of Veterinary Pathobiology, Texas A&M University, College Station, Texas 77843, USA.; Department of Molecular and Cellular Medicine, Texas A&M Health Science Center, College Station, Texas 77843, USA., Cook WE; Cook Wildlife Lab, Department of Veterinary Pathobiology, Texas A&M University, College of Veterinary Medicine and Biomedical Sciences, College Station, Texas 77843, USA.
Jazyk:	angličtina
Zdroj:	Journal of wildlife diseases [J Wildl Dis] 2024 Jan 01; Vol. 60 (1), pp. 179-183.
DOI:	10.7589/JWD-D-23-00019
Abstrakt:	Outbreaks of anthrax, caused by the soilborne bacterium Bacillus anthracis, are a continuous threat to free-ranging livestock and wildlife in enzootic regions of the United States, sometimes causing mass mortalities. Injectable anthrax vaccines are commercially available for use in livestock, and although hand injection is not a cost- or time-effective long-term management plan for prevention in wildlife, it may provide a tool for managers to target selectively animals of high conservation or economic value. Vaccine-induced anthrax-specific antibody responses have been reported previously in white-tailed deer (Odocoileus virginianus), but the protective nature was not determined. In this study, five white-tailed deer were subcutaneously vaccinated with one dose (1 mL) of the Anthrax Spore Vaccine. Eight blood collections by jugular venipuncture were conducted over 146 d to measure the anthrax-specific antibody response in each deer's serum over time. Antibodies were first detected by ELISA and later with toxin neutralization assays to estimate in vitro protection. Average peak absorbance by ELISA occurred at 14 d postvaccination, whereas average peak in vitro protection occurred at 28 d postvaccination. Observed in vitro protection on average for white-tailed deer after this single-dose vaccination protocol lasted 42-56 d postvaccination, although three individuals still maintained lethal toxin-neutralizing serum antibody titers out to 112 d postvaccination. Vaccination responses were variable but effective to some degree in all white-tailed deer. (© Wildlife Disease Association 2024.)
Databáze:	MEDLINE
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