Richter transformation - retrospective treatment outcomes analysis in Polish Adult Leukemia Study Group.

Autor: Sośnia O; Department of Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland., Pruszczyk K; Department of Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland., Danecki M; Department of Clinical Oncology, Maria Sklodowska-Curie National Research Institute of Oncology, Cracow, Poland., Wąsik-Szczepanek E; Department of Hematooncology and Bone Marrow Transplantation, Medical University, Lublin, Poland., Tryc-Szponder J; Department of Hematology and Bone Marrow Transplantation, Poznan University of Medical Sciences, Poznan, Poland., Iskierka-Jażdżewska E; Department of Hematology, Medical University of Lodz, Copernicus Memorial Hospital, Lodz, Poland., Majeranowski A; Department of Hematology and Transplantology, Medical University of Gdansk, Gdansk, Poland., Krzemień H; Department of Hematology and Bone Marrow Transplantation, Medical School of Silesia, Silesian Medical University, Katowice, Poland., Bołkun Ł; Department of Hematology, Medical University, Bialystok, Poland., Paszkiewicz-Kozik E; Department of Lymphoid Malignancies, Maria Sklodowska-Curie National Research Institute of Oncology, Warszawa, Poland., Drozd-Sokołowska J; Department of Hematology, Transplantation and Internal Medicine, Medical University, Warsaw, Poland., Kwiatkowski J; Department of Hematology and Cellular Transplantation, Lower Silesian Oncology Center, Wroclaw, Poland., Wiśniewska-Organek D; Department of Hematology, The Provincial Polyclinical Hospital, Torun, Poland., Prochorec-Sobieszek M; Department of Pathology, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland.; Diagnostic Hematology Department, Institute of Hematology and Transfusion Medicine, Warsaw, Poland., Szumera-Ciećkiewicz A; Department of Pathology, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland.; Diagnostic Hematology Department, Institute of Hematology and Transfusion Medicine, Warsaw, Poland., Budziszewska B; Department of Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland., Jamroziak K; Department of Hematology, Transplantation and Internal Medicine, Medical University, Warsaw, Poland., Hus I; Department of Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland.; Department of Hematology, Central Clinical Hospital of the Ministry of the Interior and Administration, Warsaw, Poland., Lech-Marańda E; Department of Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland., Puła B; Department of Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland.
Jazyk: angličtina
Zdroj: Leukemia & lymphoma [Leuk Lymphoma] 2024 Feb; Vol. 65 (2), pp. 175-186. Date of Electronic Publication: 2024 Jan 24.
DOI: 10.1080/10428194.2023.2277140
Abstrakt: Richter transformation (RT) is defined as developing an aggressive lymphoma in 2-10% of patients suffering from chronic lymphocytic leukemia (CLL). So far, no complex analysis of RT demographics and treatment outcomes has been performed in Poland. Thus, the retrospective analysis of 124 patients with RT from Polish hematology centers was designed. Ninety-nine patients with diffuse large B-cell lymphoma (DLBCL-RT) were identified. The median overall survival (OS) for DLBCL-RT was 17.3 months, while for Hodgkin lymphoma (HL-RT)-21.3 months. In multivariate analysis, the independent factors of worse OS for DLBCL-RT were: prior CLL therapy, ECOG stage ≥2, and elevated serum LDH activity. Patients who proceeded to hematopoietic stem cell transplantation (HSCT) achieved better results. The median OS in allogeneic HSCT recipients was not reached, while in autologous HSCT median OS was 51.3 months. In conclusion, our study represents the largest dataset of patients diagnosed with RT in Poland and confirms its dismal prognosis.
Databáze: MEDLINE
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